ArticleProceedings of the National Academy of Sciences of the United States of America2001
Insulin alters heterogeneous nuclear ribonucleoprotein K protein binding to DNA and RNA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic β cells.Molecular metabolism · 2019Article
- PIXUL-ChIP: integrated high-throughput sample preparation and analytical platform for epigenetic studies.Nucleic acids research · 2019Article
- Review
- Heterogeneous nuclear ribonucleoprotein K inhibits heat shock-induced transcriptional activity of heat shock factor 1.The Journal of biological chemistry · 2017Article
- Article
- ATM-dependent phosphorylation of heterogeneous nuclear ribonucleoprotein K promotes p53 transcriptional activation in response to DNA damage.Cell cycle (Georgetown, Tex.) · 2013Article
- Article
- Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.Human molecular genetics · 2011Article
- Direct recruitment of ERK cascade components to inducible genes is regulated by heterogeneous nuclear ribonucleoprotein (hnRNP) K.The Journal of biological chemistry · 2011Article
- Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci.Diabetes · 2011Article
- Two polypyrimidine tracts in the nitric oxide synthase 2 gene: similar regulatory sequences with different properties.Molecular biology reports · 2010Article
- A proteomic approach to identify candidate substrates of human adenovirus E4orf6-E1B55K and other viral cullin-based E3 ubiquitin ligases.Journal of virology · 2009Article
- African swine fever virus protein p30 interaction with heterogeneous nuclear ribonucleoprotein K (hnRNP-K) during infection.FEBS letters · 2008Article
- Regulatory sequence responsible for insulin destabilization of cytochrome P450 2B1 (CYP2B1) mRNA.The Biochemical journal · 2005Article
- Protein kinase CK2 phosphorylation regulates the interaction of Kaposi's sarcoma-associated herpesvirus regulatory protein ORF57 with its multifunctional partner hnRNP K.Nucleic acids research · 2004Article
- CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing.Molecular and cellular biology · 2004Article
- Nuclear shift of hnRNP K protein in neoplasms and other states of enhanced cell proliferation.British journal of cancer · 2003Article
- Transient recruitment of the hnRNP K protein to inducibly transcribed gene loci.Nucleic acids research · 2003Article
- CK2 protein kinase is stimulated and redistributed by functional herpes simplex virus ICP27 protein.Journal of virology · 2003Article
- Identification of the SRC pyrimidine-binding protein (SPy) as hnRNP K: implications in the regulation of SRC1A transcription.Nucleic acids research · 2003Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The interaction of the multimodular heterogeneous nuclear ribonucleoprotein (hnRNP) K protein with many of its protein and nucleic acid partners is regulated by extracellular signals. Acting as a docking platform, K protein could link signal-transduction pathways to DNA- and RNA-directed processes such as transcription, mRNA processing, transport, and translation. Treatment of hepatocyte culture with insulin increased K protein tyrosine phosphorylation. Insulin altered K protein interaction with RNA and DNA in vitro. Administration of insulin into mice had similar effects on K protein in liver. Coimmunoprecipitations of RNA with K protein revealed preferential in vivo K protein binding of a subset of transcripts, including the insulin-inducible c-fos mRNA. These results suggest a class of insulin pathways that signal nucleic acid-directed processes that involve K protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.