ArticleProceedings of the National Academy of Sciences of the United States of America2001
IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 101 citations in OpenAlex.
- Chemistry-mediated synthetic virus-cell interaction as a generic approach to enhance gene delivery to mammalian cells.Molecular therapy. Advances · 2026Article
- Divergent populations of HIV-infected naive and memory CD4+ T cell clones in children on antiretroviral therapy.The Journal of clinical investigation · 2025Article
- IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mechanisms of HIV-1 cell-to-cell transmission and the establishment of the latent reservoir.Virus research · 2019Review
- Baboon envelope LVs efficiently transduced human adult, fetal, and progenitor T cells and corrected SCID-X1 T-cell deficiency.Blood advances · 2019Article
- HHV-6 Specific T-Cell Immunity in Healthy Children and Adolescents.Frontiers in pediatrics · 2018Article
- Neonatal thymectomy reveals differentiation and plasticity within human naive T cells.The Journal of clinical investigation · 2016Article
- Establishment and Maintenance of the Human Naïve CD4Frontiers in pediatrics · 2016Review
- Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor.Cancer gene therapy · 2013Article
- Generation of CD4CreER(T²) transgenic mice to study development of peripheral CD4-T-cells.Genesis (New York, N.Y. : 2000) · 2012Article
- Lentiviral vectors displaying modified measles virus gp overcome pre-existing immunity in in vivo-like transduction of human T and B cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
- Glut1-mediated glucose transport regulates HIV infection.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Harnessing the biology of IL-7 for therapeutic application.Nature reviews. Immunology · 2011Review
- Protein tyrosine kinase 7: a novel surface marker for human recent thymic emigrants with potential clinical utility.Journal of perinatology : official journal of the California Perinatal Association · 2011Review
- HIV reservoirs and latency models.Virology · 2011Review
- Advances in the field of lentivector-based transduction of T and B lymphocytes for gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2010Review
- Interleukin-7 permits Th1/Tc1 maturation and promotes ex vivo expansion of cord blood T cells: a critical step toward adoptive immunotherapy after cord blood transplantation.Cancer research · 2010Article
- Redirecting the immune response: role of adoptive T cell therapy.Human gene therapy · 2010Review
- In Vivo Growing of New Cell Colonies in a Portion of Bone Marrow: Potential Use for Indirect Cell Therapy.Cell medicine · 2010Article
- Naive T cell homeostasis: from awareness of space to a sense of place.Nature reviews. Immunology · 2009Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differences in the immunological reactivity of umbilical cord (UC) and adult peripheral blood (APB) T cells are poorly understood. Here, we show that IL-7, a cytokine involved in lymphoid homeostasis, has distinct regulatory effects on APB and UC lymphocytes. Neither naive nor memory APB CD4(+) cells proliferated in response to IL-7, whereas naive UC CD4(+) lymphocytes underwent multiple divisions. Nevertheless, both naive and memory IL-7-treated APB T cells progressed into the G(1b) phase of the cell cycle, albeit at higher levels in the latter subset. The IL-7-treated memory CD4(+) lymphocyte population was significantly more susceptible to infection with an HIV-1-derived vector than dividing CD4(+) UC lymphocytes. However, activation through the T cell receptor rendered UC lymphocytes fully susceptible to HIV-1-based vector infection. These data unveil differences between UC and APB CD4(+) T cells with regard to IL-7-mediated cell cycle progression and HIV-1-based vector infectivity. This evidence indicates that IL-7 differentially regulates lymphoid homeostasis in adults and neonates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.