ArticleProceedings of the National Academy of Sciences of the United States of America2001
Folding and signaling share the same pathway in a photoreceptor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Functional insights into the photoactive yellow protein family from homologs, multidomain proteins, and inferredJournal of bacteriology · 2026Review
- Capturing the photo-signaling state of a photoreceptor in a steady-state fashion by binding a transition metal complex.Protein science : a publication of the Protein Society · 2017Article
- Optical control of protein-protein interactions via blue light-induced domain swapping.Biochemistry · 2014Article
- Nitric oxide-induced conformational changes in soluble guanylate cyclase.Structure (London, England : 1993) · 2014Article
- A circularly permuted photoactive yellow protein as a scaffold for photoswitch design.Biochemistry · 2013Article
- A conserved helical capping hydrogen bond in PAS domains controls signaling kinetics in the superfamily prototype photoactive yellow protein.Journal of the American Chemical Society · 2010Article
- Robustness and evolvability in the functional anatomy of a PER-ARNT-SIM (PAS) domain.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Modulating native-like residual structure in the fully denatured state of photoactive yellow protein affects its refolding.The Journal of biological chemistry · 2010Article
- Subpicosecond Excited-State Proton Transfer Preceding Isomerization During the Photorecovery of Photoactive Yellow Protein.The journal of physical chemistry letters · 2010Article
- ARNT PAS-B has a fragile native state structure with an alternative beta-sheet register nearby in sequence space.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Design and signaling mechanism of light-regulated histidine kinases.Journal of molecular biology · 2009Article
- Proline 54 trans-cis isomerization is responsible for the kinetic partitioning at the last-step photocycle of photoactive yellow protein.Protein science : a publication of the Protein Society · 2008Article
- Axis-dependent anisotropy in protein unfolding from integrated nonequilibrium single-molecule experiments, analysis, and simulation.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Single-molecule detection of structural changes during Per-Arnt-Sim (PAS) domain activation.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Predicting the signaling state of photoactive yellow protein.Biophysical journal · 2005Article
- Dynamical transition and proteinquake in photoactive yellow protein.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Time-resolved resonance raman structural studies of the pB' intermediate in the photocycle of photoactive yellow protein.Biophysical journal · 2004Article
- Crystal structure of a photoactive yellow protein from a sensor histidine kinase: conformational variability and signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Deuterium isotope effects in the photocycle transitions of the photoactive yellow protein.Biophysical journal · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The photoreceptor photoactive yellow protein (PYP) was used as a model system to study receptor activation and protein folding. Refolding was studied by stopped-flow absorbance spectroscopy for PYP with either a trans or a cis chromophore. Chromophore trans to cis isomerization, the mechanism of light detection by PYP, greatly affects the protein folding process. When the cis chromophore is present, refolding from the unfolded state proceeds through the putative signaling state of PYP as an on-pathway intermediate. In addition, moderate denaturant concentrations result in the specific unfolding of the signaling state of PYP. Thus, the signaling state is common to the pathways of folding and signaling. This result provides an avenue for the study of protein folding. We demonstrate how this approach can be used to establish whether a folding intermediate is on-pathway or off-pathway. The results also reveal transient partial unfolding as a molecular mechanism for signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.