ArticleCurrent infectious disease reports2001
Clinical Pharmacologic Considerations for HIV-1 Protease Inhibitors.
Article in Current infectious disease reports, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Development and validation of an LC-MS/MS quantitative method for endogenous deoxynucleoside triphosphates in cellular lysate.Biomedical chromatography : BMC · 2017Article
- Antiretroviral therapy : pharmacokinetic considerations in patients with renal or hepatic impairment.Clinical pharmacokinetics · 2008Review
- Therapeutic drug monitoring: pharmacologic considerations for antiretroviral drugs.Current HIV/AIDS reports · 2005Review
- Therapeutic drug monitoring in human immunodeficiency virus/acquired immunodeficiency syndrome. Quo vadis?Archives of pathology & laboratory medicine · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many data associate low protease inhibitor plasma concentrations with suboptimal virologic responses, whereas relatively few data associate high plasma concentrations with increased likelihood of toxicity. Knowledge of relationships between concentrations and virologic response is important because significant variability in plasma concentrations exists among HIV-infected persons. Unfortunately, a prospectively confirmed therapeutic range that reduces the risk of virologic failure has not been established for the protease inhibitors. Recent investigations have identified a relationship between the measured minimum plasma concentration, the in vitro susceptibility of the subject's virus, and virologic outcome. However, differences in virologic response may further depend on other pharmacologic factors such as protein binding, intracellular kinetics, expression of drug transporters, and drug synergies or antagonisms. In the future, dosing strategies that accommodate the variability in both pharmacokinetics and pharmacodynamics may improve virologic outcomes. In summary, clinical pharmacologic considerations for protease inhibitors can be used to promote their optimal use.
Identifiers
11470030What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.