ArticleClinical & experimental metastasis2000
Quercetin inhibits the invasion and mobility of murine melanoma B16-BL6 cells through inducing apoptosis via decreasing Bcl-2 expression.
Article in Clinical & experimental metastasis, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Quercetin and Its Nano-Based Formulations Against Skin Cancer: A Narrative Review.Health science reports · 2026Article
- Potential Antidiabetic, Antioxidative and Antiproliferative Properties of Functional Wheat Flour Muffins Enriched with White Clover Flowers (International journal of molecular sciences · 2024Article
- Spice-Derived Phenolic Compounds: Potential for Skin Cancer Prevention and Therapy.Molecules (Basel, Switzerland) · 2023Review
- Recent Advances in Phenolic Metabolites and Skin Cancer.International journal of molecular sciences · 2021Review
- Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment.International journal of nanomedicine · 2019Review
- Enhanced anti-metastatic and anti-tumorigenic efficacy of Berbamine loaded lipid nanoparticles in vivo.Scientific reports · 2017Article
- β-Lapachone suppresses the lung metastasis of melanoma via the MAPK signaling pathway.PloS one · 2017Article
- Quercetin-induced cardioprotection against doxorubicin cytotoxicity.Journal of biomedical science · 2013Article
- Phosphatase of regenerating liver-3 localizes to cyto-membrane and is required for B16F1 melanoma cell metastasis in vitro and in vivo.PloS one · 2009Article
- Significance of Bcl-xL in human colon carcinoma.World journal of gastroenterology · 2008Article
- Endonuclease G promotes cell death of non-invasive human breast cancer cells.Experimental cell research · 2006Article
- Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation.Antimicrobial agents and chemotherapy · 2006Article
- Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma.Neoplasia (New York, N.Y.) · 2005Article
- The role of Bcl-2 family members in the progression of cutaneous melanoma.Clinical & experimental metastasis · 2003Article
- PRL-3 siRNA inhibits the metastasis of B16-BL6 mouse melanoma cells in vitro and in vivo.Molecular medicine (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quercetin has been known to have anti-tumor and anti-oxidation activities. In the present study, we have investigated its in vitro anti-metastatic activity. Quercetin inhibited the invasion and mobility of murine melanoma B16-BL6 cells in a dose-dependent manner but did not affect their adhesion to either laminin, fibronectin, or type VI collagen. Moreover, quercetin significantly inhibited the proliferation of B16-BL6 cells only in the case of time incubation longer than 48 h. Quercetin dose-dependently decreased the cell rates in S and G2-M phases of cell cycle. The effect of quercetin to cause a remarkable apoptosis of B16-BL6 cells was also demonstrated by flow cytometric assay as well as DNA fragmentation with a typical 180-bp ladder band in agarose electrophoresis and a quantitative analysis. Furthermore, quercetin markedly inhibited the expression of anti-apoptotic protein Bcl-2 but hardly influenced Bcl-XL. These results suggest that the inhibition of quercetin on invasiveness and migration of B16-BL6 cells are closely associated with the arrest of cell cycle as well as the induction of apoptosis by decreasing the Bcl-2 expression.
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