ReviewJournal of mammary gland biology and neoplasia2001
Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis.
Review in Journal of mammary gland biology and neoplasia, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Review
- Signalling to eIF4E in cancer.Biochemical Society transactions · 2015Review
- Modular evolution of phosphorylation-based signalling systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Article
- Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.Cancer cell · 2009Article
- Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.Molecular cell · 2008Article
- Current development of mTOR inhibitors as anticancer agents.Nature reviews. Drug discovery · 2006Article
- Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model.The Journal of cell biology · 2005Article
- New targets for therapy in breast cancer: mammalian target of rapamycin (mTOR) antagonists.Breast cancer research : BCR · 2004Review
- Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma.The Journal of cell biology · 2002Article
- The ras signaling pathway in mammary tumorigenesis and metastasis.Journal of mammary gland biology and neoplasia · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suppression of apoptosis is now recognized as a key contributory element to tumorigenesis in animal models and human cancer. The phosphatidylinositol 3' kinase pathway plays a seminal role in cell death suppression or "survival signaling." Over the past 5 years, the molecular mechanisms by which this pathway exerts its death suppressive effects have slowly been revealed. This review summarizes the players involved, their importance in human cancer and their specific involvement in breast cancer.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.