Evidence map›Paper›PMID 11467452›Full record

ReviewJournal of mammary gland biology and neoplasia2001

Hedgehog signaling in mouse mammary gland development and neoplasia.

M T Lewis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of mammary gland biology and neoplasia, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 44 citations in OpenAlex.

  1. The Cellular Origin and Evolution of Breast Cancer.Cold Spring Harbor perspectives in medicine · 2017
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. The hedgehog pathway in breast cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2012
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Hedgehog signaling in mammary gland development and breast cancer.Journal of mammary gland biology and neoplasia · 2007
    Review
  12. Hormonal and local control of mammary branching morphogenesis.Differentiation; research in biological diversity · 2006
    Review
  13. Review
  14. Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

M T LewisUniversity of Colorado Health Sciences Center, Department of Physiology, Denver 80262, USA. mike.lewis@uchsc.edu
University of Colorado Anschutz Medical Campus · US

Funding

PHYSIOLOGICAL FACTORS AFFECTING HUMAN LACTATIONR37HD019547 · NICHD · UNIVERSITY OF COLORADO DENVER · PI NEVILLE, MARGARET C · 1993 to 2002
$856k
NICHD NIH HHS R37HD19547
6 · The paper itself

Abstract

Genetic analyses of two hedgehog signal transduction network genes, Patched-1 and Gli2, has demonstrated a critical role for hedgehog signaling in mediating epithelial-stromal tissue interactions during ductal development. Disruption of either gene leads to similar, yet distinct, defects in ductal morphogenesis. Defects are mainly ductal dysplasias that closely resemble some hyperplasias of the human breast. Phenotypic analyses have been coupled with in situ hybridization, transplantation and tissue recombination analyses to formulate a model for tissue compartment-specific control of mouse mammary gland development by hedgehog signaling. In addition, the similarities among hedgehog mutation-induced ductal dysplasias and human breast pathologies suggest a role for altered hedgehog signaling in the development of mammary cancer.

Indexed as

AnimalsBreastFemaleHumansIntracellular Signaling Peptides and ProteinsKruppel-Like Transcription FactorsMammary Neoplasms, AnimalMembrane ProteinsMiceNuclear ProteinsPatched-1 ReceptorPatched ReceptorsReceptors, Cell SurfaceSignal TransductionTranscription FactorsZinc Finger Protein Gli2GLI2 protein, humanGli2 protein, mouseIntracellular Signaling Peptides and ProteinsKruppel-Like Transcription FactorsMembrane ProteinsNuclear ProteinsPatched-1 ReceptorPatched ReceptorsPTCH1 protein, humanPtch1 protein, mouseReceptors, Cell SurfaceTranscription FactorsZinc Finger Protein Gli2

Identifiers

PMID11467452
OpenAlexW103257487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.