ReviewJournal of mammary gland biology and neoplasia2001
Wnt signaling and mammary tumorigenesis.
Review in Journal of mammary gland biology and neoplasia, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- In Vitro Anti-cancer Effect of Crataegus oxyacantha Berry Extract on Hormone Receptor Positive and Triple Negative Breast Cancers via Regulation of Canonical Wnt Signaling Pathway.Applied biochemistry and biotechnology · 2023Article
- Molecular mechanisms of anticancer activity of deoxyelephantopin in cancer cells.Integrative medicine research · 2017Article
- Molecular Signaling of Progesterone, Growth Hormone, Wnt, and HER in Mammary Glands of Dogs, Rodents, and Humans: New Treatment Target Identification.Frontiers in veterinary science · 2017Review
- Knockdown of TC-1 enhances radiosensitivity of non-small cell lung cancer via the Wnt/β-catenin pathway.Biology open · 2016Article
- Loss of SFRP1 promotes ductal branching in the murine mammary gland.BMC developmental biology · 2012Article
- Gene expression analysis of mammary tissue during fetal bud formation and growth in two pig breeds--indications of prenatal initiation of postnatal phenotypic differences.BMC developmental biology · 2012Article
- Article
- Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus.Journal of cellular biochemistry · 2012Article
- Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions.Journal of mammary gland biology and neoplasia · 2010Review
- c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland.BMC biology · 2009Article
- Stromal induction of breast cancer: inflammation and invasion.Reviews in endocrine & metabolic disorders · 2007Review
- Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells.Molecular and cellular biology · 2006Article
- The Wnt-dependent signaling pathways as target in oncology drug discovery.Investigational new drugs · 2006Review
- P53 levels determine outcome during beta-catenin tumor initiation and metastasis in the mammary gland and male germ cells.Oncogene · 2006Article
- Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma.Neoplasia (New York, N.Y.) · 2006Article
- Enhanced SMYD3 expression is essential for the growth of breast cancer cells.Cancer science · 2006Article
- Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells.Nucleic acids research · 2006Article
- A role for CK2alpha/beta in Xenopus early embryonic development.Molecular and cellular biochemistry · 2005Article
- Wnt proteins in mammary development and cancer.Journal of mammary gland biology and neoplasia · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wnt expression patterns during mammary development support a role for Wnts in breast development and in mammary epithelial responses to systemic hormones. The deregulation of Wnt signaling also plays a role in breast cancer. Activation of the Wnt signaling pathway is a major feature of several human neoplasias and appears to lead to the cytosolic stabilization of a transcriptional co-factor, beta-catenin. This co-activator can then regulate transcription from a number of target genes including the cellular oncogenes cyclin D1 and c-myc. This review will summarize the current state of knowledge of Wnt signal transduction in a range of model systems and will then address the role of Wnts and Wnt signaling in mammary development and cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.