ArticleOncogene2001
P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Sorafenib inhibited cell growth through the MEK/ERK signaling pathway in acute promyelocytic leukemia cells.Oncology letters · 2018Article
- ZNF424 Induces Apoptosis and Inhibits Proliferation in Lung Carcinoma Cells.Current molecular medicine · 2018Article
- Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway.Cell death & disease · 2014Article
- Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21Cip.Diabetologia · 2012Article
- Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy.Cell cycle (Georgetown, Tex.) · 2010Article
- The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy.Cell cycle (Georgetown, Tex.) · 2010Article
- Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs.Cell cycle (Georgetown, Tex.) · 2010Article
- Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy.Future oncology (London, England) · 2010Review
- Crystal structure of human CDK4 in complex with a D-type cyclin.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts.PloS one · 2009Article
- Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance.Biochimica et biophysica acta · 2007Review
- Regulation of CDK4.Cell division · 2006Article
- Article
- Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection.Oncogene · 2004Article
- The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells.Retrovirology · 2004Article
- Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation.Leukemia · 2003Article
- Review
- Article
- Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.Leukemia · 2003Review
- The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia.Leukemia · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To investigate the functions of the different Raf genes in hematopoietic cell proliferation, the capacities of beta-estradiol-regulated Delta Raf:ER genes to induce cell cycle regulatory gene expression and cell cycle progression in FDC-P1 cells were examined. Raf activation increased the expression of Cdk2, Cdk4, cyclin A, cyclin D, cyclin E, p21(Cip1) and c-Myc and decreased the expression of p27(Kip1) which are associated with G(1) progression. However only the cell clones with moderate Raf activation, i.e. FD/Delta Raf-1:ER and FD/Delta A-Raf:ER, successfully underwent cell proliferation. The cell clones with the highest Delta Raf activity, FD/Delta B-Raf:ER, underwent apoptosis before cell proliferation. p21(Cip1) induced by Raf activation specifically bound with Cdk4/cyclin D complexes but not Cdk2/cyclin E complexes and this binding was associated with the increased Cdk4 activity. However, no binding of p27(Kip1) with either Cdk2/cyclin E or Cdk4/cyclin D was observed. Thus Raf mediated growth was associated with elevated p21(Cip1) expression, which may specifically bind with and activate Cdk4/cyclin D complexes and with decreased p27(Kip1) expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.