ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Functional implications of neurotransmitter expression during axonal regeneration: serotonin, but not peptides, auto-regulate axon growth of an identified central neuron.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- Context-Dependent Role of miR-124 in Retinoic Acid-Induced Growth Cone Attraction of Regenerating Motorneurons.Cellular and molecular neurobiology · 2022Article
- Serotonin functions as a bidirectional guidance molecule regulating growth cone motility.Cellular and molecular life sciences : CMLS · 2021Article
- Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys.Disease models & mechanisms · 2019Article
- Peripheral sensory neurons govern development of the nervous system in bivalve larvae.EvoDevo · 2019Review
- Roles of 5-HT on phase transition of neurite outgrowth in the identified serotoninergic neuron C1, Helisoma trivolvis.Invertebrate neuroscience : IN · 2018Article
- Newly Identified Aplysia SPTR-Gene Family-Derived Peptides: Localization and Function.ACS chemical neuroscience · 2018Article
- Serotonin controls axon and neuronal regeneration in the nervous system: lessons from regenerating animal models.Neural regeneration research · 2018Article
- A Novel Approach to Primary Cell Culture forFrontiers in physiology · 2018Article
- Decreased ribosomal DNA transcription in dorsal raphe nucleus neurons differentiates between suicidal and non-suicidal death.European archives of psychiatry and clinical neuroscience · 2016Article
- Gαz regulates BDNF-induction of axon growth in cortical neurons.Molecular and cellular neurosciences · 2014Article
- Marked changes in neuropeptide expression accompany broadcast spawnings in the gastropod Haliotis asinina.Frontiers in zoology · 2012Article
- Identification of the role of C/EBP in neurite regeneration following microarray analysis of a L. stagnalis CNS injury model.BMC neuroscience · 2012Article
- Caltubin, a novel molluscan tubulin-interacting protein, promotes axonal growth and attenuates axonal degeneration of rodent neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Serotonin: a regulator of neuronal morphology and circuitry.Trends in neurosciences · 2010Review
- Transcriptome analysis of the central nervous system of the mollusc Lymnaea stagnalis.BMC genomics · 2009Article
- Neural reconnection in the transected spinal cord of the freshwater turtle Trachemys dorbignyi.The Journal of comparative neurology · 2009Article
- Identification of molluscan nicotinic acetylcholine receptor (nAChR) subunits involved in formation of cation- and anion-selective nAChRs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Development and sensitivity to serotonin of Drosophila serotonergic varicosities in the central nervous system.Developmental biology · 2005Article
- Loss of flight and associated neuronal rhythmicity in inositol 1,4,5-trisphosphate receptor mutants of Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the regenerative properties of one of two electrically coupled molluscan neurons, the serotonergic cerebral giant cells (CGCs) of Lymnaea stagnalis, after axotomy. The CGCs play a crucial role in feeding behavior, and when both cells are disconnected from their target neurons, animals no longer feed. When one CGC was permanently disconnected from its targets and the other was reversibly damaged by a nerve crush, the latter one regenerated over a period of 2 weeks to reform functional synapses with specific target neurons. At the same time, recovery of the feeding behavior was observed. After the crush, neuropeptide gene expression in the CGC was downregulated to approximately 50%. Serotonin synthesis, on the other hand, remained unaffected, suggesting that serotonin might have an active role in regeneration. In primary neuron culture, CGCs failed to extend neurites in the presence of serotonin; in cells that extended neurites in the absence of serotonin, focally applied serotonin, but not neuropeptides, induced growth cone collapse. Using serotonin-sensitive sniffer cells, we show that CGC neurites and growth cones release serotonin in culture. Finally, both the spontaneous and stimulation-induced release of serotonin from CGCs in culture resulted in growth cone collapse responses that could be blocked by the serotonin receptor antagonist methysergide. Our data suggest that auto-released serotonin is inhibitory to CGC neurite outgrowth in vitro. During regeneration in vivo, serotonin release might fine-tune axon guidance and branching by inducing local collapse responses in extending neurites.
Indexed as
Identifiers
11466431PMC6762665W1907530338What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.