ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Subunit interactions and AMPA receptor desensitization.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Allosteric competition and inhibition in AMPA receptors.Nature structural & molecular biology · 2024Article
- Article
- Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome.American journal of human genetics · 2022Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- TARPs Modulate Receptor-Mediated Paired-Pulse Depression and Recovery from Desensitization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Mechanisms of zinc modulation of olfactory bulb AMPA receptors.Neuroscience · 2019Article
- Unitary Properties of AMPA Receptors with Reduced Desensitization.Biophysical journal · 2017Article
- Superactivation of AMPA receptors by auxiliary proteins.Nature communications · 2016Article
- Ionotropic glutamate receptors: alive and kicking.The Journal of physiology · 2015Article
- Retour aux sources: defining the structural basis of glutamate receptor activation.The Journal of physiology · 2015Review
- Auxiliary proteins promote modal gating of AMPA- and kainate-type glutamate receptors.The European journal of neuroscience · 2014Article
- Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy.Nature chemical biology · 2014Article
- Identification of a probable pore-forming domain in the multimeric vacuolar anion channel AtALMT9.Plant physiology · 2013Article
- Modulation of GluK2a subunit-containing kainate receptors by 14-3-3 proteins.The Journal of biological chemistry · 2013Article
- Neto2 modulation of kainate receptors with different subunit compositions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors.Molecular neurobiology · 2010Review
- Glutamate receptor ion channels: structure, regulation, and function.Pharmacological reviews · 2010Review
- AMPA receptor desensitization mutation results in severe developmental phenotypes and early postnatal lethality.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Contribution of the global subunit structure and stargazin on the maturation of AMPA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Assembly and stoichiometry of the AMPA receptor and transmembrane AMPA receptor regulatory protein complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Most AMPA-type glutamate receptors (GluRs) exhibit rapid and virtually complete desensitization when activated by glutamate, and at some central synapses it is largely desensitization that determines the decay of EPSCs. However, the mechanisms underlying the conformation change that results in desensitization are not fully understood. AMPA receptor subunits that contain a single amino acid substitution have been shown to form homomeric channels that show markedly reduced desensitization. We show here that the coexpression of wild-type GluR1 with one such mutant, GluR1(L497Y), results in heteromeric channels that show desensitization behavior that is intermediate between wild-type and mutant homomers. The relative amplitudes of the multiple exponential components present in the decay of glutamate-evoked currents depended on the relative abundance of wild-type and mutant subunits and were described by the combinatorial distribution of the two types of subunits into tetrameric, but not pentameric, assemblies. Our results are consistent with recent structural data suggesting that AMPA receptors are tetrameric assemblies composed of two dimers.
Indexed as
Identifiers
11466429PMC6762644What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.