ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Subunit heterogeneity of cytoplasmic dynein: Differential expression of 14 kDa dynein light chains in rat hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- A role for Dynlt3 in melanosome movement, distribution, acidity and transfer.Communications biology · 2021Article
- Transgenic mouse models for studying adult neurogenesis.Frontiers in biology · 2016Article
- Aberrant Expression of Dynein light chain 1 (DYNLT1) is Associated with Human Male Factor Infertility.Molecular & cellular proteomics : MCP · 2015Article
- Phosphorylation of DYNLT1 at serine 82 regulates microtubule stability and mitochondrial permeabilization in hypoxia.Molecules and cells · 2013Article
- Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor.PloS one · 2011Article
- Chloride intracellular channel 4 is critical for the epithelial morphogenesis of RPE cells and retinal attachment.Molecular biology of the cell · 2010Article
- Identification of the Tctex-1 regulatory element that directs expression to neural stem/progenitor cells in developing and adult brain.The Journal of comparative neurology · 2010Article
- Evidence for the involvement of Lfc and Tctex-1 in axon formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells.Nature neuroscience · 2009Article
- G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth.The EMBO journal · 2007Article
- Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1.The Biochemical journal · 2005Article
- The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth.Developmental cell · 2005Article
- The gene for the intermediate chain subunit of cytoplasmic dynein is essential in Drosophila.Genetics · 2002Article
- The role of the cytoskeleton in the life cycle of viruses and intracellular bacteria: tracks, motors, and polymerization machines.Current drug targets. Infectious disorders · 2002Article
- Cytoplasmic dynein regulation by subunit heterogeneity and its role in apical transport.The Journal of cell biology · 2001Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Cytoplasmic dynein is a multi-subunit protein complex in which each subunit is encoded by a few genes. How these subunit isoforms are assembled and regulated to mediate the diverse functions of cytoplasmic dynein is unknown. We previously have shown that two highly conserved 14 kDa dynein light chains, Tctex-1 and RP3, have different cargo-binding abilities. In this report, coimmunoprecipitation revealed that Tctex-1 and RP3 were present in mutually exclusive dynein complexes of brain. Two specific antibodies were used to examine the localization of these two dynein light chains in adult rat hippocampal formation and cerebral cortex. By light microscopy, Tctex-1 and RP3 immunoreactivities exhibited distinct and almost complementary distribution patterns in both brain regions. In hippocampal formation, Tctex-1 immunoreactivity was most enriched in somata of newly generated granule cells and scant in the mature granule and pyramidal cell somata. In contrast, RP3 immunoreactivity was abundant in pyramidal and granule cell somata. Ultrastructural analysis of the dentate gyrus revealed both dynein light chains were associated with various membranous organelles that often were affiliated with microtubules. In addition, Tctex-1 and RP3 immunoreactivities were preferentially and highly enriched on membranous organelles and/or vesicles of axon terminals and dendritic spines, respectively. These results suggest that dynein complexes with different subunit composition, and possibly function, are expressed differentially in a spatially and temporally regulated manner. Furthermore, Tctex-1 and RP3 may play important roles in synaptic functions.
Indexed as
Identifiers
11466421PMC3880687W1832474731What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.