ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Developmental regulation and specific brain distribution of phosphorabphilin.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Presynaptic congenital myasthenic syndrome with altered synaptic vesicle homeostasis linked to compound heterozygous sequence variants in RPH3A.Molecular genetics & genomic medicine · 2018Article
- Control of precerebellar neuron development by Olig3 bHLH transcription factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse.Genes, brain, and behavior · 2007Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein kinases and phosphatases play an important role in modulating synaptic transmission. The synaptic protein rabphilin associates with synaptic vesicles through the small GTPase Rab3A, binds Ca(2+) and phospholipids, and interacts with cytoskeletal elements, yet its function remains controversial. In this study, we have generated phosphospecific antibodies and studied the developmental, subcellular, and brain distribution of rabphilin phosphorylated at serine-234 and serine-274. Our results show that phosphorabphilin is present in vivo under basal conditions in a specific subset of synapses. The phosphorylated rabphilin is abundant in the cerebellum, midbrain, and medulla; phosphorabphilin is specifically enriched in the climbing fiber synapses of the cerebellar cortex. Its developmental profile reveals a sharp and transient increase at approximately postnatal day 16, a period critical for the activity-dependent pruning of supernumerary climbing fibers in the cerebellum. We propose that the phosphorylation of rabphilin regulates neuronal activity through development and in a synapse-specific manner.
Indexed as
Identifiers
11466417PMC6762637W1892027897What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.