ArticleJournal of bacteriology2001
Characterization of VPI pathogenicity island and CTXphi prophage in environmental strains of Vibrio cholerae.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 118 citations in OpenAlex.
- Decoding strain level interactions betweenVirulence · 2026Article
- Revisiting the Genomic Epidemiology of Distinct Phage-TypeMicroorganisms · 2025Article
- Diversity and Complexity of CTXΦ and Pre-CTXΦ Families inMicroorganisms · 2024Article
- Enabling genomic island prediction and comparison in multiple genomes to investigate bacterial evolution and outbreaks.Microbial genomics · 2022Article
- Cholera toxin phage: structural and functional diversity betweenAIMS microbiology · 2020Review
- Novel Cholera Toxin Variant and ToxT Regulon in EnvironmentalApplied and environmental microbiology · 2019Article
- Structural basis for virulence regulation inCommunications biology · 2019Article
- Environmental role of pathogenic traits inJournal of bacteriology · 2018Article
- Changing facades ofThe Indian journal of medical research · 2018Review
- The Hybrid Pre-CTXΦ-RS1 Prophage Genome and Its Regulatory Function in Environmental Vibrio cholerae O1 Strains.Applied and environmental microbiology · 2015Article
- Clonal Dissemination of a Single Vibrio cholerae O1 Biotype El Tor Strain in Sistan-Baluchestan Province of Iran During 2013.Current microbiology · 2015Article
- Survival and proliferation of the lysogenic bacteriophage CTXΦ in Vibrio cholerae.Virologica Sinica · 2015Review
- Molecular tools in understanding the evolution of Vibrio cholerae.Frontiers in microbiology · 2015Review
- Occurrence in Mexico, 1998-2008, of Vibrio cholerae CTX+ El Tor carrying an additional truncated CTX prophage.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A molecular surveillance reveals the prevalence of Vibrio cholerae O139 isolates in China from 1993 to 2012.Journal of clinical microbiology · 2014Article
- The seventh pandemic Vibrio cholerae O1 El Tor isolate in China has undergone genetic shifts.Journal of clinical microbiology · 2014Article
- Genomic science in understanding cholera outbreaks and evolution of Vibrio cholerae as a human pathogen.Current topics in microbiology and immunology · 2014Review
- Cholera: Environmental Reservoirs and Impact on Disease Transmission.Microbiology spectrum · 2013Article
- Article
- Population structure and evolution of non-O1/non-O139 Vibrio cholerae by multilocus sequence typing.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Environmental isolates of Vibrio cholerae of eight randomly amplified polymorphic DNA (RAPD) fingerprint types from Calcutta, India, that were unusual in containing toxin-coregulated pilus or cholera toxin genes but not O1 or O139 antigens of epidemic strains were studied by PCR and sequencing to gain insights into V. cholerae evolution. We found that each isolate contained a variant form of the VPI pathogenicity island. Distinguishing features included (i) four new alleles of tcpF (which encodes secreted virulence protein; its exact function is unknown), 20 to 70% divergent (at the protein level) from each other and canonical tcpF; (ii) a new allele of toxT (virulence regulatory gene), 36% divergent (at the protein level) in its 5' half and nearly identical in its 3' half to canonical toxT; (iii) a new tcpA (pilin) gene; and (iv) four variant forms of a regulatory sequence upstream of toxT. Also found were transpositions of an IS903-related element and function-unknown genes to sites in VPI. Cholera toxin (ctx) genes were found in isolates of two RAPD types, in each case embedded in CTXphi-like prophages. Fragments that are inferred to contain only putative repressor, replication, and integration genes were present in two other RAPD types. New possible prophage repressor and replication genes were also identified. Our results show marked genetic diversity in the virulence-associated gene clusters found in some nonepidemic V. cholerae strains, suggest that some of these genes contribute to fitness in nature, and emphasize the potential importance of interstrain gene exchange in the evolution of this species.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.