ArticleArchives of disease in childhood2001
Diagnostic assessment of haemorrhagic rash and fever.
Article in Archives of disease in childhood, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03378258 (Petechiae In Children), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Petechiae In Children (PIC) Study
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- A systematic review of the diagnostic accuracy of Loop-mediated-isothermal AMPlification (LAMP) in the diagnosis of invasive meningococcal disease in children.BMC pediatrics · 2019Pooled it
- Rare Cases Can Provide Too Much Reassurance About Meningitis After the Neonatal Period.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Purpuric rash and fever among hospitalized children aged 0-18 years: Comparison between clinical, laboratory, therapeutic and outcome features of patients with bacterial versus viral etiology.Pediatrics and neonatology · 2019Article
- Article
- A protocol for a systematic review of the diagnostic accuracy of Loop-mediated-isothermal AMPlification (LAMP) in diagnosis of invasive meningococcal disease in children.Systematic reviews · 2018Article
- [Meningococcal infections associated with febrile purpura among children hospitalized in a Moroccan Hospital: incidence and associated clinical factors].The Pan African medical journal · 2017Article
- Article
- [Hemorrhagic skin lesions associated with infections].Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde · 2012Article
- Signs and symptoms in children with a serious infection: a qualitative study.BMC family practice · 2005Article
- Diagnosis and Management of Enteroviral Infections of the Central Nervous System.Current infectious disease reports · 2002Article
- Prevalence and distribution of petechiae in well babies.Archives of disease in childhood · 2002Article
- Radial osteomyelitis as a complication of venous cannulation.Archives of disease in childhood · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo establish criteria for early distinction between meningococcal disease and other conditions with similar clinical features, and to identify other causes for haemorrhagic rashes accompanied by fever.
methodsIn a prospective study, 264 infants and children hospitalised with fever and skin haemorrhages were studied.
resultsWe identified an aetiological agent in 28%: 15% had meningococcal disease, 2% another invasive bacterial infection, 7% enterovirus infection, and 4% adenovirus infection. Five clinical variables distinguished between meningococcal disease and other conditions on admission: (1) skin haemorrhages of characteristic appearance; (2) universal distribution of skin haemorrhages; (3) maximum diameter of one or more skin haemorrhages greater than 2 mm; (4) poor general condition (using a standardised observation scheme); and (5) nuchal rigidity. If any two or more of these clinical variables were present, the probability of identifying a patient with meningococcal disease was 97% and the false positive rate was only 12%. This diagnostic algorithm did not identify children in whom septicaemia was caused by other bacterial species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.