Trial reportArchives of disease in childhood2001
Persistent wheezing in infants with an atopic tendency responds to inhaled fluticasone.
Trial report in Archives of disease in childhood, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 74 citations in OpenAlex.
- Treatment of Severe Acute Asthma is Damage Control.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2013Article
- The management of pre-school wheeze.Paediatric respiratory reviews · 2011Review
- An approach to preschool wheezing: to label as asthma?The World Allergy Organization journal · 2010Article
- Wheeze in preschool children.BMJ (Clinical research ed.) · 2008Article
- How has research changed my practice in the last 5 years?Archives of disease in childhood · 2007Article
- Management of unresponsive asthma.Indian journal of pediatrics · 2004Review
- Research in general paediatrics.Archives of disease in childhood · 2004Article
- How do we treat wheezing infants? Evidence or anecdote.Archives of disease in childhood · 2002Article
- Diagnosing asthma in young children.Current allergy and asthma reports · 2002Review
- Difficult asthma in children.Thorax · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of inhaled corticosteroids for the treatment of wheeze in infancy remains unclear.
aimTo investigate the effect of inhaled fluticasone on symptoms in a group of wheezy infants who had a high risk of progressing to childhood asthma.
methodsA total of 52 infants, under 1 year of age, with a history of wheeze or cough and a history (personal or first degree relative) of atopy were prescribed either 150 microg fluticasone twice daily (group F) or placebo (group P), via metered dose inhaler, for 12 weeks following a two week run in period. Symptoms were scored in a parent held diary and the mean daily symptom score (MDS) and symptom free days (SFD) calculated for each two week period.
resultsThirty seven infants completed the study. Both MDS and SFD improved significantly between the run in and final two week period in group F, but not group P, with a mean difference in change (95% CI) between groups of 1.12 (0.05 to 2.18) for MDS and median difference of 3.0 (0.002 to 8.0) for SFD.
conclusionImprovement of clinical symptoms in response to fluticasone can be shown in this high risk group of infants. In the absence of effective alternatives inhaled corticosteroids should be considered in this patient group.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.