ReviewCNS drugs2001
The star systems: overview and use in determining antiepileptic drug choice.
Review in CNS drugs, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Current Principles in the Management of Drug-Resistant Epilepsy.CNS drugs · 2022Article
- Ionic and synaptic mechanisms of seizure generation and epileptogenesis.Neurobiology of disease · 2019Review
- Methods for Incorporating Patient Preferences for Treatments of Depression in Community Mental Health Settings.Administration and policy in mental health · 2017Article
- Emerging drugs for partial-onset epilepsy: a review of brivaracetam.Therapeutics and clinical risk management · 2016Article
- Treatment of epilepsy in China: Formal or informal.Neural regeneration research · 2013Article
- Anticonvulsant and related neuropharmacological effects of the whole plant extract of Synedrella nodiflora (L.) Gaertn (Asteraceae).Journal of pharmacy & bioallied sciences · 2012Article
- Thirty years of clinical experience with carbamazepine in the treatment of bipolar illness: principles and practice.CNS drugs · 2007Review
- Review
- The use of multiattribute decision models in evaluating triptan treatment options in migraine.Journal of neurology · 2005Article
- Medical therapy of epilepsy: when to initiate treatment and when to combine?Journal of neurology · 2005Review
- Prioritizing treatment attributes and their impact on selecting an oral triptan: results from the TRIPSTAR Project.Current pain and headache reports · 2004Review
- The natural history of epilepsy: an epidemiological view.Journal of neurology, neurosurgery, and psychiatry · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An explosion in antiepileptic drug (AED) therapy began in the 1990s with the licensing of 9 new chemical entities and more to come. Important differences between AEDs may not be detected by regulatory trials, which are designed to satisfy licensing requirements and often diverge considerably from everyday clinical practice. The Star Systems have been developed as evidence-based yet pragmatic and flexible models for comparing AEDs. Each drug has been judged across a range of criteria, including mechanism of action, pharmacokinetics, ease of use, efficacy, tolerability, safety, interaction profile and a 'comfort factor'. A score has been allocated under each category and systems have been devised for patients with newly diagnosed epilepsy and those with difficult-to-control seizures requiring combination therapy. The choice of treatment should involve assessment of patient-related factors, accurate classification of seizure type and syndrome, married with an understanding of the pharmacology of the AEDs. A staged management plan should be formulated when initiating treatment with the aim of preventing the development of refractory epilepsy. When using combinations of AEDs, the mechanism of action of each agent should be taken into consideration. Such an individualised approach to management will optimise the chance of attaining remission and help many more patients achieve a fulfilling life.
Indexed as
Identifiers
11465010What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.