ArticleMolecular and cellular biology2001
Reconstitution of cyclin D1-associated kinase activity drives terminally differentiated cells into the cell cycle.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 93 citations in OpenAlex.
- Cell cycle criticality as a mechanism for robust cell population control.Molecular systems biology · 2026Article
- Structural obstruction to full DNA replication in terminally differentiated skeletal muscle cells.EMBO reports · 2025Article
- ACV with/without IVM: a new talk on intestinal CDX2 and muscular CD34 and Cyclin D1 duringHelminthologia · 2024Article
- Cellular and transcriptomic changes by the supplementation of aged rat serum in human pluripotent stem cell-derived myogenic progenitors.Frontiers in cell and developmental biology · 2024Article
- Skeletal Muscle Nuclei in Mice are not Post-mitotic.Function (Oxford, England) · 2023Article
- Restoring the Cell Cycle and Proliferation Competence in Terminally Differentiated Skeletal Muscle Myotubes.Cells · 2021Review
- MITO-Luc/GFP zebrafish model to assess spatial and temporal evolution of cell proliferation in vivo.Scientific reports · 2021Article
- Inhibiting 4E-BP1 re-activation represses podocyte cell cycle re-entry and apoptosis induced by adriamycin.Cell death & disease · 2019Article
- Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI).Journal of molecular and cellular cardiology · 2019Article
- CDK4 inhibition diminishes p53 activation by MDM2 antagonists.Cell death & disease · 2018Article
- Controlling Depth of Cellular Quiescence by an Rb-E2F Network Switch.Cell reports · 2017Article
- A defective dNTP pool hinders DNA replication in cell cycle-reactivated terminally differentiated muscle cells.Cell death and differentiation · 2017Article
- ROS and Brain Gliomas: An Overview of Potential and Innovative Therapeutic Strategies.International journal of molecular sciences · 2016Review
- Proliferation of Multiple Cell Types in the Skeletal Muscle Tissue Elicited by Acute p21 Suppression.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- The heart: mostly postmitotic or mostly premitotic? Myocyte cell cycle, senescence, and quiescence.The Canadian journal of cardiology · 2014Review
- Epstein-Barr virus infection and persistence in nasopharyngeal epithelial cells.Chinese journal of cancer · 2014Review
- Redox regulation of endothelial cell fate.Cellular and molecular life sciences : CMLS · 2014Article
- Retinoblastoma protein and MyoD function together to effect the repression of Fra-1 and in turn cyclin D1 during terminal cell cycle arrest associated with myogenesis.The Journal of biological chemistry · 2014Article
- Modelling mammalian cellular quiescence.Interface focus · 2014Review
- Levels matter: miR-206 and cyclin D1.Cell cycle (Georgetown, Tex.) · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Terminal cell differentiation entails definitive withdrawal from the cell cycle. Although most of the cells of an adult mammal are terminally differentiated, the molecular mechanisms preserving the postmitotic state are insufficiently understood. Terminally differentiated skeletal muscle cells, or myotubes, are a prototypic terminally differentiated system. We previously identified a mid-G(1) block preventing myotubes from progressing beyond this point in the cell cycle. In this work, we set out to define the molecular basis of such a block. It is shown here that overexpression of highly active cyclin E and cdk2 in myotubes induces phosphorylation of pRb but cannot reactivate DNA synthesis, underscoring the tightness of cell cycle control in postmitotic cells. In contrast, forced expression of cyclin D1 and wild-type or dominant-negative cdk4 in myotubes restores physiological levels of cdk4 kinase activity, allowing progression through the cell cycle. Such reactivation occurs in myotubes derived from primary, as well as established, C2C12 myoblasts and is accompanied by impairment of muscle-specific gene expression. Other terminally differentiated systems as diverse as adipocytes and nerve cells are similarly reactivated. Thus, the present results indicate that the suppression of cyclin D1-associated kinase activity is of crucial importance for the maintenance of the postmitotic state in widely divergent terminally differentiated cell types.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.