ArticleBiophysical journal2001
U-type inactivation of Kv3.1 and Shaker potassium channels.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 83 citations in OpenAlex.
- Use-dependent regulation of the axonal action potential in parvalbumin-expressing interneurons.bioRxiv : the preprint server for biology · 2026Article
- KChIP1 splice variants modulate Kv4 channels by promoting P/C-type inactivation features.Scientific reports · 2026Article
- Stability of N-type inactivation and the coupling between N-type and C-type inactivation in the Aplysia Kv1 channel.Pflugers Archiv : European journal of physiology · 2024Article
- Activity-dependent modulation of neuronal KThe Journal of biological chemistry · 2022Article
- Inactivation of Native K Channels.The Journal of membrane biology · 2022Article
- AFrontiers in pharmacology · 2022Article
- High-Resolution Structures of KHandbook of experimental pharmacology · 2021Article
- The activation gate controls steady-state inactivation and recovery from inactivation in Shaker.The Journal of general physiology · 2020Article
- KV1.2 channels inactivate through a mechanism similar to C-type inactivation.The Journal of general physiology · 2020Article
- The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels.Biophysical journal · 2020Article
- Gating and Regulation of KCNQ1 and KCNQ1 + KCNE1 Channel Complexes.Frontiers in physiology · 2020Review
- Polyunsaturated fatty acids inhibit Kv1.4 by interacting with positively charged extracellular pore residues.American journal of physiology. Cell physiology · 2016Article
- Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons.Journal of neurophysiology · 2016Article
- The tetramerization domain potentiates Kv4 channel function by suppressing closed-state inactivation.Biophysical journal · 2014Article
- K⁺ channel gating: C-type inactivation is enhanced by calcium or lanthanum outside.The Journal of general physiology · 2014Article
- Shaker IR T449 mutants separate C- from U-type inactivation.The Journal of membrane biology · 2014Article
- Role of outer-pore residue Y380 in U-type inactivation of KV2.1 channels.The Journal of membrane biology · 2013Article
- Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels.The Journal of general physiology · 2012Article
- Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule.The Journal of general physiology · 2012Article
- Transfer of Kv3.1 voltage sensor features to the isolated Ci-VSP voltage-sensing domain.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We previously concluded that the Kv2.1 K(+) channel inactivates preferentially from partially activated closed states. We report here that the Kv3.1 channel also exhibits two key features of this inactivation mechanism: a U-shaped voltage dependence measured at 10 s and stronger inactivation with repetitive pulses than with a single long depolarization. More surprisingly, slow inactivation of the Kv1 Shaker K(+) channel (Shaker B Delta 6--46) also has a U-shaped voltage dependence for 10-s depolarizations. The time and voltage dependence of recovery from inactivation reveals two distinct components for Shaker. Strong depolarizations favor inactivation that is reduced by K(o)(+) or by partial block by TEA(o), as previously reported for slow inactivation of Shaker. However, depolarizations near 0 mV favor inactivation that recovers rapidly, with strong voltage dependence (as for Kv2.1 and 3.1). The fraction of channels that recover rapidly is increased in TEA(o) or high K(o)(+). We introduce the term U-type inactivation for the mechanism that is dominant in Kv2.1 and Kv3.1. U-type inactivation also makes a major but previously unrecognized contribution to slow inactivation of Shaker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.