ArticleBiophysical journal2001
The optical stretcher: a novel laser tool to micromanipulate cells.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
252 citing papers in PubMed, 968 citations in OpenAlex.
- Measuring the Elastic Properties of Living Cells.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Selective photoacoustic handling of microparticles via annular laser beams.Microsystems & nanoengineering · 2026Article
- SmartTrap: automated precision experiments with optical tweezers.Nature methods · 2026Article
- High-Resolution Optical Chromatography: Principles, Innovations, and Emerging Biomedical Applications.Micromachines · 2026Review
- Comparative mechanical profiling of MCF-7 cells in 2D and 3D cultures via optical tweezers.Biomedical optics express · 2026Article
- PPy-Coated Wire Actuators for the Micromechanostimulation of Cells: Fabrication and Characterization.Small science · 2026Article
- Impact of staining on cell acoustic properties.Biophysical journal · 2026Article
- Looking at endometriosis-diagnosis and disease mechanisms through a mechanical lens.Frontiers in medicine · 2026Review
- Multiscale measurement of brain tissue and cell biomechanics using a mouse model.Biophysics reports · 2025Article
- Radiation-pressure-induced surface deformation of transparent liquids due to laser beams under oblique incidence.Photoacoustics · 2025Article
- B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses.FEBS letters · 2025Review
- Pathophysiological Associations and Measurement Techniques of Red Blood Cell Deformability.Biosensors · 2025Review
- Ultra-long-range optical pulling with an optical nanofibre.Nature communications · 2025Article
- Effects of Shear and Extensional Stresses on Cells: Investigation in a Spiral Microchannel and Contraction-Expansion Arrays.ACS biomaterials science & engineering · 2025Review
- Morphometric effects of particulate air pollution on an optically trapped single red blood cell.Scientific reports · 2025Article
- Review
- Optical trapping of mesoscale particles and atoms in hollow-core optical fibers: principle and applications.Light, science & applications · 2025Review
- Dual-fiber optical tweezers integrating high-sensitivity structured-light displacement measurement system on fiber end-face.Scientific reports · 2025Article
- Robust quantification of cellular mechanics using optical tweezers.Biophysical reports · 2025Article
- Rapid Stiffness Mapping in Soft Biologic Tissues With Micrometer Resolution Using Optical Multifrequency Time-Harmonic Elastography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
192 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
When a dielectric object is placed between two opposed, nonfocused laser beams, the total force acting on the object is zero but the surface forces are additive, thus leading to a stretching of the object along the axis of the beams. Using this principle, we have constructed a device, called an optical stretcher, that can be used to measure the viscoelastic properties of dielectric materials, including biologic materials such as cells, with the sensitivity necessary to distinguish even between different individual cytoskeletal phenotypes. We have successfully used the optical stretcher to deform human erythrocytes and mouse fibroblasts. In the optical stretcher, no focusing is required, thus radiation damage is minimized and the surface forces are not limited by the light power. The magnitude of the deforming forces in the optical stretcher thus bridges the gap between optical tweezers and atomic force microscopy for the study of biologic materials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.