ArticleThe Biochemical journal2001
Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Identification of sodium homeostasis genes in Camelus bactrianus by whole transcriptome sequencing.FEBS open bio · 2022Article
- Insights Into the Peroxisomal Protein Inventory of Zebrafish.Frontiers in physiology · 2022Article
- Two Pex5 Proteins With Different Cargo Specificity Are Critical for Peroxisome Function in Ustilago maydis.Frontiers in cell and developmental biology · 2022Article
- Comparative Genomics of Peroxisome Biogenesis Proteins: Making Sense of the PEX Proteins.Frontiers in cell and developmental biology · 2021Article
- Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels.The Journal of biological chemistry · 2017Article
- Characterization of proteome dynamics during growth in oleate reveals a new peroxisome-targeting receptor.Journal of cell science · 2016Article
- Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.Neurobiology of disease · 2016Article
- Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.Autophagy · 2015Article
- Clathrin-mediated endocytosis and adaptor proteins.Acta naturae · 2013Article
- Association of adaptor protein TRIP8b with clathrin.Journal of neurochemistry · 2011Article
- Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6.BMC cell biology · 2009Article
- Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Peroxisome senescence in human fibroblasts.Molecular biology of the cell · 2002Article
- Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins.The Biochemical journal · 2002Article
- Interaction of calcium-independent latrotoxin receptor with intracellular adapter protein TRIP8b.Doklady. Biochemistry and biophysicsArticle
- The fast and slow ups and downs of HCN channel regulation.Channels (Austin, Tex.)Review
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on peroxin protein 5 (Pex5p) homology searches in the expressed sequence tag database and sequencing of large full-length cDNA inserts, three novel and related human cDNAs were identified. The brain-derived cDNAs coded for two related proteins that differ only slightly at their N-terminus, and exhibit 39.8% identity to human PEX5p. The shorter liver-derived cDNA coded for the C-terminal tetratricopeptide repeat-containing domain of the brain cDNA-encoded proteins. Since these three proteins specifically bind to various C-terminal peroxisome-targeting signals in a manner indistinguishable from Pex5p and effectively compete with Pex5p in an in vitro peroxisome-targeting signal 1 (PTS1)-binding assay, we refer to them as 'Pex5p-related proteins' (Pex5Rp). In contrast to Pex5p, however, human PEX5Rp did not bind to Pex14p or to the RING finger motif of Pex12p, and could not restore PTS1 protein import in Pex5(-/-) mouse fibroblasts. Immunofluorescence analysis of epitope-tagged PEX5Rp in Chinese hamster ovary cells suggested an exclusively cytosolic localization. Northern-blot analysis showed that the PEX5R gene, which is localized to chromosome 3q26.2--3q27, is expressed preferentially in brain. Mouse PEX5Rp was also delineated. In addition, experimental evidence established that the closest-related yeast homologue, YMR018wp, did not bind PTS1. Based on its subcellular localization and binding properties, Pex5Rp may function as a regulator in an early step of the PTS1 protein import process.
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