Evidence map›Paper›PMID 11462052›Full record

ArticleJournal of virology2001

Retroviral splicing suppressor requires three nonconsensus uridines in a 5' splice site-like sequence.

R E Paca, C S Hibbert, C T O'Sullivan, K L Beemon

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. RNA processing control in avian retroviruses.Frontiers in bioscience : a journal and virtual library · 2008
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. SRp30c is a repressor of 3' splice site utilization.Molecular and cellular biology · 2002
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

R E PacaDepartment of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA.
C S Hibbert
C T O'Sullivan
K L Beemon
Johns Hopkins University · US

Funding

RETROVIRAL REGULATORY SEQUENCES WITHIN CODING SEQUENCESR01CA048746 · NCI · JOHNS HOPKINS UNIVERSITY · PI BEEMON, KAREN L. · 1989 to 2014
$4.6M
NCI NIH HHS R01 CA048746NCI NIH HHS R01 CA48746PHS HHS 52T32G07231
6 · The paper itself

Abstract

Rous sarcoma virus RNA contains a negative regulator of splicing (NRS) element that aids in maintenance of unspliced RNA. The NRS binds U1 snRNA at a sequence that deviates from the 5' splice site consensus by substitution of U's for A's at three positions: -2, +3, and +4. All three of these U's are important for NRS-mediated splicing suppression. Substitution of a single nonconsensus C or G at any of these sites diminished NRS activity, whereas substitution of a single A generated a preferred 5' splice site within the NRS.

Indexed as

RNA SplicingAnimalsAvian Sarcoma VirusesRNA, ViralRNA, Viral

Identifiers

PMID11462052
PMCPMC115015
OpenAlexW2019746779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.