ArticleJournal of virology2001
E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed, 90 citations in OpenAlex.
- Mitochondrial targeting by measles virus nucleoprotein modulates viral spread in human airway epithelium.PLoS pathogens · 2025Article
- BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps.Molecular neurodegeneration · 2023Article
- BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps.Research square · 2023Article
- A kinetic fluorescence polarization ligand assay for monitoring BAX early activation.Cell reports methods · 2022Article
- LZ-101, a novel derivative of danofloxacin, induces mitochondrial apoptosis by stabilizing FOXO3a via blocking autophagy flux in NSCLC cells.Cell death & disease · 2019Article
- Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction.Cell death & disease · 2015Article
- E1B and E4 oncoproteins of adenovirus antagonize the effect of apoptosis inducing factor.Virology · 2014Article
- hTERT extends the life of human fibroblasts without compromising type I interferon signaling.PloS one · 2013Article
- Role of mitofusin 2 in the renal stress response.PloS one · 2012Article
- The oncolytic adenovirus AdΔΔ enhances selective cancer cell killing in combination with DNA-damaging drugs in pancreatic cancer models.Gene therapy · 2011Article
- Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax.Journal of virology · 2011Article
- Reactive oxygen species is essential for cycloheximide to sensitize lexatumumab-induced apoptosis in hepatocellular carcinoma cells.PloS one · 2011Article
- Prevention of apoptosis by the interaction between FIH1 and Bax.Molecular and cellular biochemistry · 2011Article
- Tyrosine dephosphorylation is required for Bak activation in apoptosis.The EMBO journal · 2010Article
- Article
- Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.Molecular cell · 2009Article
- The fowlpox virus BCL-2 homologue, FPV039, interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis.Journal of virology · 2009Article
- Biphasic modulation of apoptotic pathways in Cryptosporidium parvum-infected human intestinal epithelial cells.Infection and immunity · 2009Article
- A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.Genes & development · 2007Article
- Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism.The Journal of clinical investigation · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Tumor necrosis factor alpha (TNF-alpha)-mediated death signaling causes the recruitment of monomeric pro- apoptotic Bax into a 500-kDa protein complex. The adenovirus Bcl-2 homologue, E1B 19K, inhibits TNF-alpha-mediated apoptosis, interacts with Bax, and blocked the formation of the 500-kDa Bax complex. TNF-alpha and truncated Bid induced Bax-Bax cross-linking, indicative of oligomerization, and E1B 19K expression during infection inhibited this TNF-alpha-mediated Bax oligomerization. TNF-alpha signaled conformation changes at the Bax amino and carboxy termini. Exposure of the Bax amino terminus facilitates E1B 19K-Bax binding, which prevented exposure of the carboxy-terminal Bax Bcl-2 homology region 2 epitope. Inhibition of Bax oligomerization by E1B 19K is an activity that bears striking similarity to the means by which bacterial immunity proteins block pore formation by bacterial toxins which have structural homology to Bax.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.