ArticleProceedings of the National Academy of Sciences of the United States of America2001
Stationary-phase mutation in the bacterial chromosome: recombination protein and DNA polymerase IV dependence.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 116 citations in OpenAlex.
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- Selective Inbreeding: Genetic Crosses Drive Apparent Adaptive Mutation in the Cairns-Foster System ofGenetics · 2020Article
- Mutation and Recombination Rates Vary Across Bacterial Chromosome.Microorganisms · 2019Review
- Selection and Plasmid Transfer Underlie Adaptive Mutation inGenetics · 2018Article
- Processing closely spaced lesions during Nucleotide Excision Repair triggers mutagenesis in E. coli.PLoS genetics · 2017Article
- Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli.PLoS genetics · 2017Article
- RNA Primer Extension Hinders DNA Synthesis byFrontiers in microbiology · 2017Article
- Conserved rates and patterns of transcription errors across bacterial growth states and lifestyles.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The DNA polymerase III holoenzyme contains γ and is not a trimeric polymerase.Nucleic acids research · 2016Article
- Roles of Nucleoid-Associated Proteins in Stress-Induced Mutagenic Break Repair in Starving Escherichia coli.Genetics · 2015Article
- Translesion DNA polymerases.Cold Spring Harbor perspectives in biology · 2013Review
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- Translesion DNA Synthesis.EcoSal Plus · 2012Article
- Two mechanisms produce mutation hotspots at DNA breaks in Escherichia coli.Cell reports · 2012Article
- Stress-induced mutation via DNA breaks in Escherichia coli: a molecular mechanism with implications for evolution and medicine.BioEssays : news and reviews in molecular, cellular and developmental biology · 2012Article
- Culture history and population heterogeneity as determinants of bacterial adaptation: the adaptomics of a single environmental transition.Microbiology and molecular biology reviews : MMBR · 2012Review
- Impact of a stress-inducible switch to mutagenic repair of DNA breaks on mutation in Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Minisatellite alterations in ZRT1 mutants occur via RAD52-dependent and RAD52-independent mechanisms in quiescent stationary phase yeast cells.DNA repair · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Several microbial systems have been shown to yield advantageous mutations in slowly growing or nongrowing cultures. In one assay system, the stationary-phase mutation mechanism differs from growth-dependent mutation, demonstrating that the two are different processes. This system assays reversion of a lac frameshift allele on an F' plasmid in Escherichia coli. The stationary-phase mutation mechanism at lac requires recombination proteins of the RecBCD double-strand-break repair system and the inducible error-prone DNA polymerase IV, and the mutations are mostly -1 deletions in small mononucleotide repeats. This mutation mechanism is proposed to occur by DNA polymerase errors made during replication primed by recombinational double-strand-break repair. It has been suggested that this mechanism is confined to the F plasmid. However, the cells that acquire the adaptive mutations show hypermutation of unrelated chromosomal genes, suggesting that chromosomal sites also might experience recombination protein-dependent stationary-phase mutation. Here we test directly whether the stationary-phase mutations in the bacterial chromosome also occur via a recombination protein- and pol IV-dependent mechanism. We describe an assay for chromosomal mutation in cells carrying the F' lac. We show that the chromosomal mutation is recombination protein- and pol IV-dependent and also is associated with general hypermutation. The data indicate that, at least in these male cells, recombination protein-dependent stationary-phase mutation is a mechanism of general inducible genetic change capable of affecting genes in the bacterial chromosome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.