ArticleProceedings of the National Academy of Sciences of the United States of America2001
Myosin I mutants with only 1% of wild-type actin-activated MgATPase activity retain essential in vivo function(s).
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- A novel highly antifungal compound ZJS-178 targeting myosin I inhibits the endocytosis and mycotoxin biosynthesis of Fusarium graminearum.Crop health · 2024Article
- UCS Chaperone Folding of the Myosin Head: A Function That Evolved before Animals and Fungi Diverged from a Common Ancestor More than a Billion Years Ago.Biomolecules · 2022Review
- Effects of Mutations in the Phenamacril-Binding Site ofACS omega · 2020Article
- The fungal myosin I is essential for Fusarium toxisome formation.PLoS pathogens · 2018Article
- Kinetic Adaptations of Myosins for Their Diverse Cellular Functions.Traffic (Copenhagen, Denmark) · 2016Review
- Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis.Infection and immunity · 2016Article
- Article
- Molecular basis of dynamic relocalization of Dictyostelium myosin IB.The Journal of biological chemistry · 2012Article
- The myosin motor domain of fungal chitin synthase V is dispensable for vesicle motility but required for virulence of the maize pathogen Ustilago maydis.The Plant cell · 2010Article
- Human deafness mutation E385D disrupts the mechanochemical coupling and subcellular targeting of myosin-1a.Biophysical journal · 2008Article
- Hyphal growth: a tale of motors, lipids, and the Spitzenkörper.Eukaryotic cell · 2007Review
- Cytokinesis depends on the motor domains of myosin-II in fission yeast but not in budding yeast.Molecular biology of the cell · 2005Article
- CsmA, a class V chitin synthase with a myosin motor-like domain, is localized through direct interaction with the actin cytoskeleton in Aspergillus nidulans.Molecular biology of the cell · 2005Article
- Cellular distribution and functions of wild-type and constitutively activated Dictyostelium PakB.Molecular biology of the cell · 2005Article
- Functional characterization of myosin I tail regions in Candida albicans.Eukaryotic cell · 2004Article
- Crystal structure of the motor domain of a class-I myosin.The EMBO journal · 2002Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The single class I myosin (MYOA) of Aspergillus nidulans is essential for hyphal growth. It is generally assumed that the functions of all myosins depend on their actin-activated MgATPase activity. Here we show that MYOA mutants with no more than 1% of the actin-activated MgATPase activity of wild-type MYOA in vitro and no detectable in vitro motility activity can support fungal cell growth, albeit with a delay in germination time and a reduction in hyphal elongation. From these and other data, we conclude that the essential role(s) of myosin I in A. nidulans is probably structural, requiring little, if any, actin-activated MgATPase or motor activity, which have long been considered the defining characteristics of the myosin family.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.