ReviewNature2001
Gene silencing as an adaptive defence against viruses.
Review in Nature, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 298 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
298 citing papers in PubMed.
- Virus-Induced Gene Silencing for Nodulation Analysis in Soybean.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Envisaging the role of plant Small RNAs: A comprehensive review on antiviral defense mechanisms.Molecular biology reports · 2026Review
- Epigenetic and Epitranscriptomic Antiviral Responses in Plants for Disease Management.Viruses · 2025Review
- Reinfection Dynamics of Disease-Free Cassava Plants in Three Agroecological Regions of Côte d'Ivoire.Viruses · 2025Article
- A novel self-assembled nanocarrier-mediated dsRNA fungicide for broad-spectrum management ofMaterials today. Bio · 2025Article
- Double-Stranded DNA Reduces dsRNA Degradation in the Saliva and Significantly Enhanced RNAi-Mediated Gene Silencing in Halyomorpha halys.Advanced biology · 2025Article
- Analysis and simulation of a novel stochastic RNA silencing model.Scientific reports · 2025Article
- Viral coat proteins decrease the gene silencing activity of cognate and heterologous viral suppressors.Scientific reports · 2024Article
- Opportunities for Riboswitch Inhibition by Targeting Co-Transcriptional RNA Folding Events.International journal of molecular sciences · 2024Review
- Challenges and Opportunities Arising from Host-International journal of molecular sciences · 2024Review
- Exogenous Application of dsRNA in Plant Protection: Efficiency, Safety Concerns and Risk Assessment.International journal of molecular sciences · 2024Review
- Article
- How molecular techniques are developed from natural systems.Genetics · 2023Article
- Geminiviral betasatellites: critical viral ammunition to conquer plant immunity.Archives of virology · 2023Review
- Establishing a Virus-Induced Gene Silencing System inPlants (Basel, Switzerland) · 2023Article
- RNA Interference Past and Future Applications in Plants.International journal of molecular sciences · 2023Review
- SEMI-ROLLED LEAF 10 stabilizes catalase isozyme B to regulate leaf morphology and thermotolerance in rice (Oryza sativa L.).Plant biotechnology journal · 2023Article
- The curious case of genome packaging and assembly in RNA viruses infecting plants.Frontiers in genetics · 2023Review
- CRISPR technology towards genome editing of the perennial and semi-perennial crops citrus, coffee and sugarcane.Frontiers in plant science · 2023Review
- Article
238 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene silencing was perceived initially as an unpredictable and inconvenient side effect of introducing transgenes into plants. It now seems that it is the consequence of accidentally triggering the plant's adaptive defence mechanism against viruses and transposable elements. This recently discovered mechanism, although mechanistically different, has a number of parallels with the immune system of mammals.
Indexed as
Identifiers
11459066What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.