ArticleGenetics2001
Genetic analysis of the Drosophila Gs(alpha) gene.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Sex-specific signaling in the blood-brain barrier is required for male courtship in Drosophila.PLoS genetics · 2013Article
- Parasite neuropeptide biology: Seeding rational drug target selection?International journal for parasitology. Drugs and drug resistance · 2012Review
- The stimulatory Gα(s) protein is involved in olfactory signal transduction in Drosophila.PloS one · 2011Article
- Identification of a specific assembly of the g protein golf as a critical and regulated module of dopamine and adenosine-activated cAMP pathways in the striatum.Frontiers in neuroanatomy · 2011Article
- Article
- Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Gsalpha is involved in sugar perception in Drosophila melanogaster.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Article
- Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras.Human molecular genetics · 2006Article
- Vibrio cholerae infection of Drosophila melanogaster mimics the human disease cholera.PLoS pathogens · 2005Article
- Molecular and comparative genetics of mental retardation.Genetics · 2004Article
- Presynaptic impairment of synaptic transmission in Drosophila embryos lacking Gs(alpha).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the best understood signal transduction pathways activated by receptors containing seven transmembrane domains involves activation of heterotrimeric G-protein complexes containing Gs(alpha), the subsequent stimulation of adenylyl cyclase, production of cAMP, activation of protein kinase A (PKA), and the phosphorylation of substrates that control a wide variety of cellular responses. Here, we report the identification of "loss-of-function" mutations in the Drosophila Gs(alpha) gene (dgs). Seven mutants have been identified that are either complemented by transgenes representing the wild-type dgs gene or contain nucleotide sequence changes resulting in the production of altered Gs(alpha) protein. Examination of mutant alleles representing loss-of-Gs(alpha) function indicates that the phenotypes generated do not mimic those created by mutational elimination of PKA. These results are consistent with the conclusion reached in previous studies that activation of PKA, at least in these developmental contexts, does not depend on receptor-mediated increases in intracellular cAMP, in contrast to the predictions of models developed primarily on the basis of studies in cultured cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.