ArticleGenetics2001
Genetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- PKA restricts ERK signaling in learning and memory Kenyon cell neurons.Cellular signalling · 2025Article
- Fragile X Mental Retardation Protein positively regulates PKA anchor Rugose and PKA activity to control actin assembly in learning/memory circuitry.Neurobiology of disease · 2019Article
- A Kinome RNAi Screen inG3 (Bethesda, Md.) · 2017Article
- Postsynaptic glutamate receptors regulate local BMP signaling at the Drosophila neuromuscular junction.Development (Cambridge, England) · 2014Article
- Axonal injury and regeneration in the adult brain of Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Drosophila Costal1 mutations are alleles of protein kinase A that modulate hedgehog signaling.Genetics · 2004Article
- Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis.Developmental biology · 2002Article
- Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.BMC developmental biology · 2002Article
- Hemocytes are essential for wing maturation in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hedgehog (Hh) activates a signal transduction pathway regulating Cubitus interruptus (Ci). In the absence of Hh, full-length Ci (Ci-155) is bound in a complex that includes Costal2 (Cos2) and Fused (Fu). Ci-155 is phosphorylated by protein kinase A (PKA), inducing proteolysis to Ci-75, a transcriptional repressor. Hh signaling blocks proteolysis and produces an activated Ci-155 transcriptional activator. The relationship between PKA and the Ci/Cos2/Fu complex is unclear. Here we examine Hh target gene expression caused by mutant forms of PKA regulatory (PKAr) and catalytic (PKAc) subunits and by the PKAc inhibitor PKI(1-31). The mutant PKAr*, defective in binding cAMP, is shown to activate Hh target genes solely through its ability to bind and inhibit endogenous PKAc. Surprisingly, PKAcA75, a catalytically impaired mutant, also activates Hh target genes. To account for this observation, we propose that PKAc phosphorylation targeting Ci-155 for proteolysis is regulated within a complex that includes PKAc and Ci-155 and excludes PKI(1-31). This complex may permit processive phosphorylation of Ci-155 molecules, facilitating their processing to Ci-75.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.