ArticleGenetics2001
DNA variation at the rp49 gene region of Drosophila simulans: evolutionary inferences from an unusual haplotype structure.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 117 citations in OpenAlex.
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- Genetic Diversity and Natural Selection ofFrontiers in microbiology · 2021Article
- A fully integrated machine learning scan of selection in the chimpanzee genome.NAR genomics and bioinformatics · 2020Article
- Impacts of local population history and ecology on the evolution of a globally dispersed pathogen.BMC genomics · 2020Article
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- Usefulness of a multiplex PCR for the rapid identification of Candida glabrata species complex in Mexican clinical isolates.Revista do Instituto de Medicina Tropical de Sao Paulo · 2019Article
- Recent Secondary Contacts, Linked Selection, and Variable Recombination Rates Shape Genomic Diversity in the Model Species Anolis carolinensis.Genome biology and evolution · 2019Article
- Extent and Dynamics of Polymorphism in the Malaria Vaccine CandidateThe American journal of tropical medicine and hygiene · 2018Article
- PopHuman: the human population genomics browser.Nucleic acids research · 2018Article
- On the Evolution and Function ofFrontiers in genetics · 2018Article
- How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data.Genetics and molecular biology · 2018Article
- Identifying PotentialFrontiers in genetics · 2018Article
- A Large Panel of Drosophila simulans Reveals an Abundance of Common Variants.Genome biology and evolution · 2018Article
- Multiple gene genealogy reveals high genetic diversity and evidence for multiple origins of Chinese Plasmopara viticola population.Scientific reports · 2017Article
- Molecular Population Genetics.Genetics · 2017Review
- Imbalanced positive selection maintains the functional divergence of duplicated DIHYDROKAEMPFEROL 4-REDUCTASE genes.Scientific reports · 2016Article
7 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An approximately 1.3-kb region including the rp49 gene plus its 5' and 3' flanking regions was sequenced in 24 lines of Drosophila simulans (10 from Spain and 14 from Mozambique). Fifty-four nucleotide and 8 length polymorphisms were detected. All nucleotide polymorphisms were silent: 52 in noncoding regions and 2 at synonymous sites in the coding region. Estimated silent nucleotide diversity was similar in both populations (pi = 0.016, for the total sample). Nucleotide variation revealed an unusual haplotype structure showing a subset of 11 sequences with a single polymorphism. This haplotype was present at intermediate frequencies in both the European and the African samples. The presence of such a major haplotype in a highly recombining region is incompatible with the neutral equilibrium model. This haplotype structure in both a derived and a putatively ancestral population can be most parsimoniously explained by positive selection. As the rate of recombination in the rp49 region is high, the target of selection should be close to or within the region studied.
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