ArticleAnnals of the rheumatic diseases2001
Specific glycosylation of alpha(1)-acid glycoprotein characterises patients with familial Mediterranean fever and obligatory carriers of MEFV.
Article in Annals of the rheumatic diseases, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Impact of Mediterranean Fever Gene Mutations on Clinical Characteristics in Patients With Inflammatory Bowel Disease.Gastro hep advances · 2026Article
- Glycoprotein analysis using lectin microcolumns and capillary electrophoresis: Characterization of alphaJournal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2021Article
- TLR-4 polymorphisms and leukocyte TLR-4 expression in febrile UTI and renal scarring.Pediatric nephrology (Berlin, Germany) · 2013Article
- Relationship between serum interleukin-1beta levels and acute phase response proteins in patients with familial Mediterranean fever.Biochemia medica · 2012Article
- Article
- Fucosylation of serum alpha1-acid glycoprotein in rheumatoid arthritis patients treated with infliximab.Clinical rheumatology · 2007Article
- CATERPILLERs, pyrin and hereditary immunological disorders.Nature reviews. Immunology · 2006Review
- Common mutations in the familial Mediterranean fever gene associate with rapid progression to disability in non-Ashkenazi Jewish multiple sclerosis patients.Genes and immunity · 2003Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFamilial Mediterranean fever (FMF) is a periodic febrile disorder, characterised by fever and serositis. The acute phase response during attacks of FMF results from the release of cytokines, which in turn induce increased expression and changed glycosylation of acute phase proteins. A recent study indicated that attacks in FMF are accompanied by a rise of plasma concentrations of serum amyloid A (SAA) and C reactive protein (CRP), which remain significantly raised during remission relative to healthy controls. Another study suggested that obligatory heterozygotes also display an inflammatory acute phase response.
objectiveTo determine the state of inflammation in homozygotic and heterozygotic MEFV genotypes.
methodsCRP and SAA were studied by enzyme linked immunosorbent assay (ELISA). The glycosylation of the acute phase protein, alpha(1)-acid glycoprotein (AGP), was visualised with crossed affinoimmunoelectrophoresis with concanavalin A as diantennary glycan-specific component and Aleuria aurantia lectin as fucose-specific affinity component.
resultsFMF attacks were associated with an increase (p<0.05) in the serum inflammation parameters CRP, SAA, and AGP. The glycosylation of AGP showed an increase (p<0.05) in fucosylated AGP glycoforms, whereas the branching of the glycans remained unaffected. The glycosylation of AGP in the MEFV carrier group, compared with that in a healthy control group, was characterised by a significant increase (p<0.05) in branching of the glycans, whereas the fucosylation remained unaffected.
conclusionThe findings suggest an FMF-specific release of cytokines, resulting in a different glycosylation of AGP between a homozygotic and heterozygotic MEFV genotype.
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