ArticleImmunology2001
Endocytosis and recycling of the complex between CD23 and HLA-DR in human B cells.
Article in Immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 75 citations in OpenAlex.
- B Cell Activation, Differentiation, and Their Potential Molecular Mechanisms in Osteoarthritic Synovial Tissue.Journal of inflammation research · 2025Article
- Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype.Mucosal immunology · 2023Article
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- The Potential of Exosomes in Allergy Immunotherapy.Vaccines · 2022Review
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- Filling the Antibody Pipeline in Allergy: PIPE Cloning of IgE, IgGInternational journal of molecular sciences · 2020Article
- Kinetics of cytokine receptor internalization under steady-state conditions affects growth of neighboring blood cells.Haematologica · 2020Article
- IgE Antibodies: From Structure to Function and Clinical Translation.Antibodies (Basel, Switzerland) · 2019Review
- A Mechanism for the Development of Chronic Traumatic Encephalopathy From Persistent Traumatic Brain Injury.Journal of experimental neuroscience · 2019Article
- CD23 surface density on B cells is associated with IgE levels and determines IgE-facilitated allergen uptake, as well as activation of allergen-specific T cells.The Journal of allergy and clinical immunology · 2017Article
- Immunoglobulin E, what is it good for?Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Review
- High affinity targeting of CD23 inhibits IgE synthesis in human B cells.Immunity, inflammation and disease · 2015Article
- Targeting antigens to dendritic cell receptors for vaccine development.Journal of drug delivery · 2013Review
- CD23b isoform expression in human schistosomiasis identifies a novel subset of activated B cells.Infection and immunity · 2011Article
- Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases.Immunological reviews · 2011Review
- CD23 Sheddase A disintegrin and metalloproteinase 10 (ADAM10) is also required for CD23 sorting into B cell-derived exosomes.The Journal of biological chemistry · 2010Article
- Murine B cells regulate serum IgE levels in a CD23-dependent manner.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- CD23/FcεRII: molecular multi-tasking.Clinical and experimental immunology · 2010Review
- ADAM8: a new therapeutic target for asthma.Expert opinion on therapeutic targets · 2009Review
- Isolation and phenotypic characterization of mucosal nasal lymphocytes by direct ex vivo analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presentation of extremely low doses of antigen to T cells is enhanced by immunoglobulin E (IgE)-dependent antigen focusing to CD23, the low-affinity receptor for IgE, expressed on activated B cells. CD23 contains a C-type lectin domain in its extracellular sequence and a targeting signal for coated pits, required for endocytosis, in its cytoplasmic sequence. CD23 is non-covalently associated with the major histocompatibility complex class II antigen, human leucocyte antigen HLA-DR, on the surface of human B cells, but the fate of this complex following endocytosis is unknown. To answer this question we have labelled these proteins on the surface of RPMI 8866 B cells and traced their route through the cytoplasm. Endocytosis mediated by anti-CD23 antibodies (BU38 and MHM6) led to the loss of CD23 from the cells. Endocytosis mediated by an antibody to HLA-DR (CR3/43) or an antigen-IgE complex (NP-BSA-anti-NP IgE), however, led to recycling of the HLA-DR-CD23 complex to the cell surface on a time scale (3-6 hr) consistent with the recycling of HLA-DR in antigen presentation. Along the latter pathway CD23 label was observed in cytoplasmic organelles that resembled the 'compartments for peptide loading' or 'class II vesicles' described by previous authors. Two features of the recycling process may contribute to the efficiency of antigen presentation. Peptide exchange may be facilitated by the proximity of HLA-DR and antigen in peptide loading compartments of the endosomal network. The return of CD23 with HLA-DR to the cell surface may then help to stabilize specific B-cell-T-cell interactions, contributing to T-cell activation.
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