ArticleNucleic acids research2001
Regulation of CCAAT/enhancer-binding protein-beta isoform synthesis by alternative translational initiation at multiple AUG start sites.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
- Metformin inhibits human non-small cell lung cancer by regulating AMPK-CEBPB-PDL1 signaling pathway.Cancer immunology, immunotherapy : CII · 2022Article
- C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer.Nature communications · 2022Article
- CCAAT/enhancer binding protein β is dispensable for development of lung adenocarcinoma.PloS one · 2015Article
- TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation.The Journal of clinical investigation · 2014Article
- Article
- Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities.PLoS pathogens · 2012Article
- Negative regulation of miR-145 by C/EBP-β through the Akt pathway in cancer cells.Nucleic acids research · 2012Article
- C/EBPβ binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells.Journal of cellular physiology · 2011Article
- LIP expression is regulated by IGF-1R signaling and participates in suppression of anoikis.Molecular cancer · 2011Article
- CCAAT/enhancer-binding protein beta inhibits proliferation in monocytic cells by affecting the retinoblastoma protein/E2F/cyclin E pathway but is not directly required for macrophage morphology.The Journal of biological chemistry · 2011Article
- The Ric-8B gene is highly expressed in proliferating preosteoblastic cells and downregulated during osteoblast differentiation in a SWI/SNF- and C/EBPbeta-mediated manner.Molecular and cellular biology · 2011Article
- Liver-enriched inhibitory protein (LIP) actively inhibits preadipocyte differentiation through histone deacetylase 1 (HDAC1).The Journal of biological chemistry · 2011Article
- Upstream open reading frames: molecular switches in (patho)physiology.BioEssays : news and reviews in molecular, cellular and developmental biology · 2010Review
- Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury in mice.Neurochemistry international · 2010Article
- Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.The EMBO journal · 2009Article
- CCAAT/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases.Expert reviews in molecular medicine · 2009Review
- Insulin regulates TRB3 and other stress-responsive gene expression through induction of C/EBPbeta.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription.Nucleic acids research · 2008Article
- Distinct functions of CCAAT enhancer-binding protein isoforms in the regulation of manganese superoxide dismutase during interleukin-1beta stimulation.The Journal of biological chemistry · 2008Article
- Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT/enhancer-binding protein-beta.Molecular endocrinology (Baltimore, Md.) · 2008Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The mRNA of the intronless, single-copy CCAAT/enhancer-binding protein-beta (C/EBPbeta) gene encodes several isoforms that have truncated transcription activation domains. This occurs by the alternative translational initiation (ATI) at multiple AUG start sites. The C/EBPbeta mRNA has four in-frame AUGs and an internal out-of-frame AUG associated with a small open reading frame (sORF). Initiation of translation at the in-frame AUGs forms 40-kDa (AUG-1), 35-kDa (AUG-2), 20-kDa (AUG-3) and 8.5-kDa (AUG-4) isoforms. We show that in COS-1 cells the 20-kDa isoform is not a product of proteolysis of the higher molecular weight isoforms. The sORF contains an AUG and termination signal that may produce the oligopeptide MPPAAARRL. Our studies suggest that ATI involves three mRNA structural features: (i) the cap structure, (ii) the context of the Kozak sequences that flank the AUG and (iii) the integrity of the sORF. We propose that formation of C/EBPbeta isoforms is accomplished by a leaky ribosomal scanning mechanism that facilitates ATI of multiple internal AUGs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.