ArticleMolecular biology of the cell2001
Etoposide induces the dispersal of DNA ligase I from replication factories.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Increased sensitivity of etoposide-treated breast cancer cells with an ATM inhibitor.PloS one · 2026Article
- DNA repair pathway-related proteins are involved in the circularization step of microDNA eccDNACommunications biology · 2025Article
- The interplay of TARG1 and PARG protects against genomic instability.Cell reports · 2023Article
- A missense MT-ND5 mutation in differentiated Parkinson Disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA.Scientific reports · 2017Article
- Review
- Review
- Molecular mechanisms of etoposide.EXCLI journal · 2015Review
- Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed.Cell death & disease · 2014Article
- Uracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed.Molecular cancer therapeutics · 2013Article
- Antioxidant enzymes reduce DNA damage and early activation of valvular interstitial cells in aortic valve sclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- More forks on the road to replication stress recovery.Journal of molecular cell biology · 2011Review
- Phosphorylation of human DNA ligase I regulates its interaction with replication factor C and its participation in DNA replication and DNA repair.Molecular and cellular biology · 2009Article
- Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.The Journal of cell biology · 2008Article
- DNA replication: a complex matter.EMBO reports · 2003Review
- Multiple roles for kinases in DNA replication.EMBO reports · 2003Review
- The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene.Molecular and cellular biology · 2003Article
- Human chromosomes 9, 12, and 15 contain the nucleation sites of stress-induced nuclear bodies.Molecular biology of the cell · 2002Article
- Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins.The EMBO journal · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotic cells DNA replication occurs in specific nuclear compartments, called replication factories, that undergo complex rearrangements during S-phase. The molecular mechanisms underlying the dynamics of replication factories are still poorly defined. Here we show that etoposide, an anticancer drug that induces double-strand breaks, triggers the redistribution of DNA ligase I and proliferating cell nuclear antigen from replicative patterns and the ensuing dephosphorylation of DNA ligase I. Moreover, etoposide triggers the formation of RPA foci, distinct from replication factories. The effect of etoposide on DNA ligase I localization is prevented by aphidicolin, an inhibitor of DNA replication, and by staurosporine, a protein kinase inhibitor and checkpoints' abrogator. We suggest that dispersal of DNA ligase I is triggered by an intra-S-phase checkpoint activated when replicative forks meet topoisomerase II-DNA--cleavable complexes. However, etoposide treatment of ataxia telangiectasia cells demonstrated that ataxia-telangiectasia-mutated activity is not required for the disassembly of replication factories and the formation of replication protein A foci.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.