ArticleAntimicrobial agents and chemotherapy2001
Molecular characterization of chromosomal class C beta-lactamase and its regulatory gene in Ochrobactrum anthropi.
Article in Antimicrobial agents and chemotherapy, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Opportunistic infections by Brucella anthropi and Brucella intermedia: a case series of rare non-brucellosis diseases in Saudi Arabia.BMC infectious diseases · 2025Article
- Ochrobactrum anthropi infection following corneal transplantation -a case report and review of literature.BMC ophthalmology · 2024Review
- Class C β-Lactamases: Molecular Characteristics.Clinical microbiology reviews · 2022Review
- Genomics ofMicrobial genomics · 2021Article
- The GenusMicroorganisms · 2020Review
- Genomic Characterization of Antimicrobial Resistance, Virulence, and Phylogeny of the GenusAntibiotics (Basel, Switzerland) · 2020Article
- Bacterial isolation from internal organs of rats (Veterinary world · 2019Article
- Genome-Guided Characterization ofInternational journal of environmental research and public health · 2018Article
- The Growing Genetic and Functional Diversity of Extended Spectrum Beta-Lactamases.BioMed research international · 2018Review
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- Article
- Draft genome of Ochrobactrum intermedium strain M86 isolated from non-ulcer dyspeptic individual from India.Gut pathogens · 2013Article
- Clinical characteristics of Ochrobactrum anthropi bacteremia.Journal of clinical microbiology · 2013Article
- Beta-lactam antibiotics: from antibiosis to resistance and bacteriology.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2010Review
- Multilocus sequence typing supports the hypothesis that Ochrobactrum anthropi displays a human-associated subpopulation.BMC microbiology · 2009Article
- Article
- AmpC beta-lactamases.Clinical microbiology reviews · 2009Review
- Antibacterial activities of multi drug resistant Myroides odoratimimus bacteria isolated from adult flesh flies (Diptera: sarcophagidae) are independent of metallo beta-lactamase gene.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2008Article
- A semi-quantitative GeLC-MS analysis of temporal proteome expression in the emerging nosocomial pathogen Ochrobactrum anthropi.Genome biology · 2007Article
- Beta-lactamase nomenclature.Antimicrobial agents and chemotherapy · 2006Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ochrobactrum anthropi, formerly known as CDC group Vd, is an oxidase-producing, gram-negative, obligately aerobic, non-lactose-fermenting bacillus of low virulence that occasionally causes human infections. It is highly resistant to all beta-lactams except imipenem. A clinical isolate, SLO74, and six reference strains were tested. MICs of penicillins, aztreonam, and most cephalosporins tested, including cefotaxime and ceftazidime, were >128 microg/ml and of cefepime were 64 to >128 microg/ml. Clavulanic acid was ineffective and tazobactam had a weak effect in association with piperacillin. Two genes, ampR and ampC, were cloned by inserting restriction fragments of genomic DNA from the clinical strain O. anthropi SLO74 into pBK-CMV to give the recombinant plasmid pBK-OA1. The pattern of resistance to beta-lactams of this clone was similar to that of the parental strain, except for its resistance to cefepime (MIC, 0.5 ,micro/ml). The deduced amino acid sequence of the AmpC beta-lactamase (pI, 8.9) was only 41 to 52% identical to the sequence of other chromosomally encoded and plasmid-encoded class C beta-lactamases. The kinetic properties of this beta-lactamase were typical for this class of beta-lactamases. Upstream from the ampC gene, the ampR gene encodes a protein with a sequence that is 46 to 62% identical to those of other AmpR proteins and with an amino-terminal DNA-binding domain typical of transcriptional activators of the Lys-R family. The deduced amino acid sequences of the ampC genes of the six reference strains were 96 to 99% identical to the sequence of the clinical strain. The beta-lactamase characterized from strain SLO74 was named OCH-1 (gene, bla(OCH-I)).
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