ArticleAntimicrobial agents and chemotherapy2001
Telithromycin is active against Mycobacterium avium in mice despite lacking significant activity in standard in vitro and macrophage assays and is associated with low frequency of resistance during treatment.
Article in Antimicrobial agents and chemotherapy, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Exposure ofMicroorganisms · 2020Article
- Quantitative analysis ofClinical proteomics · 2019Article
- Article
- Chemotherapeutic interventions against tuberculosis.Pharmaceuticals (Basel, Switzerland) · 2012Article
- EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium.Antimicrobial agents and chemotherapy · 2007Article
- Optimization of cholesterol removal by probiotics in the presence of prebiotics by using a response surface method.Applied and environmental microbiology · 2005Article
- A subinhibitory concentration of clarithromycin inhibits Mycobacterium avium biofilm formation.Antimicrobial agents and chemotherapy · 2004Article
- Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice.Antimicrobial agents and chemotherapy · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The activity of telithromycin, a new ketolide, was evaluated in vitro and in vivo against Mycobacterium avium complex (MAC) strains. The MIC of telithromycin for several M. avium isolates obtained from the blood of AIDS patients ranged from 16 to >128 microg/ml (MIC at which 90% of isolates are inhibited, >128 microg/ml), and the compound did show activity in the macrophage system at concentrations greater than 8 or 16 microg/ml, but this was dependent on the MAC strain used. Telithromycin was then administered to mice infected with MAC strain 101 for 4 weeks at doses of 100, 200, or 400 mg/kg of body weight/day. Treatment with 100 and 200 mg/kg/day was bacteriostatic, but at 400 mg/kg/day telithromycin was bactericidal for MAC strains. The frequency of the emergence of resistance to telithromycin was low despite prolonged usage (12 weeks). This study demonstrates that telithromycin is active in vivo against MAC and warrants further evaluation.
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