ArticleJournal of epidemiology and community health2001
Do genetic factors contribute to the association between birth weight and blood pressure?
Article in Journal of epidemiology and community health, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 62 citations in OpenAlex.
- Genetic and environmental determinants of population variation in interleukin-6, its soluble receptor and C-reactive protein: insights from identical and fraternal twins.Brain, behavior, and immunity · 2015Article
- The relationship between body mass index and uric acid: a study on Japanese adult twins.Environmental health and preventive medicine · 2015Article
- Familial aggregation and childhood blood pressure.Current hypertension reports · 2015Review
- Article
- Early-life origins of adult disease: national longitudinal population-based study of the United States.American journal of public health · 2011Article
- Birth weight effects on children's mental, motor, and physical development: evidence from twins data.Maternal and child health journal · 2009Article
- Undernutrition and obesity associated with high blood pressure in children and adolescents from João Pessoa, Paraíba, Brazil.Pediatric cardiology · 2009Article
- Birth weight, puberty, and systolic blood pressure in children and adolescents: a longitudinal analysis.Journal of human hypertension · 2006Article
- Hypotheses on the fetal origins of adult diseases: contributions of epidemiological studies.European journal of epidemiology · 2006Review
- Leukocyte telomere length and physical ability among Danish twins age 70+.Mechanisms of ageing and developmentArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
objectivesTo evaluate whether genetic factors contribute to the association between low birth weight and increased blood pressure among adolescents.
designHistorical cohort study of twin pairs. It was evaluated whether (1) a negative association between birth weight and systolic blood pressure was found in the overall twin sample and (2) whether the intrapair difference in birth weight correlated with the intrapair difference in systolic blood pressure-thereby controlling for the effect of genetic factors (all in monozygotic and on average half in dizygotic pairs).
settingThe Minnesota Twin Family Study.
participants1311 pairs of adolescent twins. MAIN
resultsA negative association between birth weight and systolic blood pressure was retrieved in the overall sample. The regression coefficient after controlling for current weight was -1.88 mm Hg/kg (SE 0.61), which corresponds to results from previous studies of singleton adolescents. The regression coefficient fell to -0.64 mm Hg/kg (SE 0.86) when the intrapair analyses were used. The largest reduction was observed among monozygotic twins: from -2.44 mm Hg/kg (SE 0.75) in the overall monozygotic twin sample to -1.06 mm Hg/kg (SE 1.14) in the analyses of the within monozygotic pair differences.
conclusionThe association between low birth weight and increased blood pressure later in life is well established. "The fetal programming hypothesis" suggests that the association is caused by intrauterine malnutrition while a new hypothesis "the fetal insulin hypothesis" proposes that genetically determined insulin resistance also contributes significantly to the association. A recent twin study of middle aged twins showed no evidence for an influence of genetic factors while this larger study provides support for the fetal insulin hypothesis: the association between birth weight and blood pressure attenuated among adolescents when genetic factors were controlled. Together this suggests an important contribution of genetic factors to the association between fetal growth and systolic blood pressure in adolescence.
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