ArticleThe EMBO journal2001
A novel meiosis-specific protein of fission yeast, Meu13p, promotes homologous pairing independently of homologous recombination.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Hop2-Mnd1 and Swi5-Sfr1 stimulate Dmc1 filament assembly using distinct mechanisms.Nucleic acids research · 2023Article
- The Hop2-Mnd1 Complex and Its Regulation of Homologous Recombination.Biomolecules · 2023Review
- Time to match; when do homologous chromosomes become closer?Chromosoma · 2022Article
- Two auxiliary factors promote Dmc1-driven DNA strand exchange via stepwise mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Immediate visualization of recombination events and chromosome segregation defects in fission yeast meiosis.Chromosoma · 2019Article
- The telomere bouquet facilitates meiotic prophase progression and exit in fission yeast.Cell discovery · 2017Article
- Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe.Chromosoma · 2016Article
- DNA strand exchange and RecA homologs in meiosis.Cold Spring Harbor perspectives in biology · 2014Review
- The third exon of the budding yeast meiotic recombination gene HOP2 is required for calcium-dependent and recombinase Dmc1-specific stimulation of homologous strand assimilation.The Journal of biological chemistry · 2014Article
- Article
- The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.Cell cycle (Georgetown, Tex.) · 2010Article
- High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I.Cell cycle (Georgetown, Tex.) · 2010Article
- Article
- Cohesin and recombination proteins influence the G1-to-S transition in azygotic meiosis in Schizosaccharomyces pombe.Genetics · 2008Article
- DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena.Journal of cell science · 2008Article
- Meiotic Recombination in Schizosaccharomyces pombe: A Paradigm for Genetic and Molecular Analysis.Genome dynamics and stability · 2008Article
- Prelude to a division.Annual review of cell and developmental biology · 2008Review
- Mcp4, a meiotic coiled-coil protein, plays a role in F-actin positioning during Schizosaccharomyces pombe meiosis.Eukaryotic cell · 2007Article
- Meiosis specific coiled-coil proteins in Shizosaccharomyces pombe.Cell division · 2007Article
- An analysis of univalent segregation in meiotic mutants of Arabidopsis thaliana: a possible role for synaptonemal complex.Genetics · 2007Article
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Authors and funding
4 authors.
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Abstract
Meiotic homologous pairing is crucial to proper homologous recombination, which secures subsequent reductional chromosome segregation. We have identified a novel meiosis-specific protein of fission yeast Schizosaccharomyces pombe, Meu13p, to be a molecule that is required for proper homologous pairing and recombination. Rec12p (homologue of Saccharomyces cerevisiae Spo11p), which is essential for the initiation of meiotic recombination, is also shown for the first time to participate in the pairing process of S.pombe. Meu13p, however, contributes to pairing through a recombination-independent mechanism, as disruption of the meu13(+) gene reduces pairing whether the rec12(+) gene is deleted or not. We also demonstrate a dynamic nature of homologous pairing in living meiotic cells, which is markedly affected by meu13 deletion. Meu13p is not required for telomere clustering and the nuclear movement process, which are well known requirements for efficient pairing in S.pombe. Based on these results, together with the localization of Meu13p on meiotic chromatin, we propose that Meu13p directly promotes proper homologous pairing and recombination.
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