ArticleGenes & development2001
SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 98 citations in OpenAlex.
- Th1 Cytokines Inhibit Acinar Morphogenesis and Milk Protein Expression in 3D Mammary Cultures.Biomedicines · 2025Article
- Elevated levels of exogenous prolactin promote inflammation at the maternal-fetal interface via the JAK2/STAT5B signaling axis.Frontiers in immunology · 2024Article
- CEBPA-Regulated Expression ofFoods (Basel, Switzerland) · 2023Article
- The Mammary Gland: Basic Structure and Molecular Signaling during Development.International journal of molecular sciences · 2022Review
- A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.PLoS genetics · 2017Article
- Angiotensin II accelerates mammary gland development independently of high blood pressure in pregnancy-associated hypertensive mice.Physiological reports · 2015Article
- Cytokine networks that mediate epithelial cell-macrophage crosstalk in the mammary gland: implications for development and cancer.Journal of mammary gland biology and neoplasia · 2014Review
- Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERα(+) tumorigenesis.Cell death and differentiation · 2014Article
- Breast cancer: the menacing face of Janus kinase.Cell death and differentiation · 2014Article
- STAT signaling in mammary gland differentiation, cell survival and tumorigenesis.Molecular and cellular endocrinology · 2014Review
- Precision genetics for complex objectives in animal agriculture.Journal of animal science · 2010Article
- Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.Leukemia · 2008Review
- Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B.Genes & development · 2008Review
- Prolactin regulation of mammary gland development.Journal of mammary gland biology and neoplasia · 2008Review
- Genomewide analysis of secretory activation in mouse models.Journal of mammary gland biology and neoplasia · 2007Article
- The declining phase of lactation: peripheral or central, programmed or pathological?Journal of mammary gland biology and neoplasia · 2007Review
- c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3.The EMBO journal · 2006Article
- Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation.The Journal of biological chemistry · 2006Article
- Alveolar and lactogenic differentiation.Journal of mammary gland biology and neoplasia · 2006Review
- Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells.Molecular and cellular biology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolactin is essential for proliferation and differentiation of the developing mammary gland. We have explored a role for Suppressor of Cytokine Signaling 1 (SOCS1) as a modulator of the prolactin response using mice deficient in SOCS1, which were rescued from neonatal death by deletion of the Interferon gamma (IFN gamma) gene. SOCS1(-/-)/IFN gamma(-/-) mice exhibited accelerated lobuloalveolar development in the mammary gland during late pregnancy and precocious lactation. Significantly, the lactogenic defect in prolactin receptor heterozygous females could be rescued by deletion of a single SOCS1 allele. These findings establish a role for SOCS1 as a negative regulator of prolactin signaling and suggest that SOCS1 is required for the prevention of lactation prior to parturition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.