Evidence map›Paper›PMID 11444386›Full record

ReviewImmunologic research2001

Immune recognition, response, and regulation: how T lymphocytes do it.

S Joyce

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. CD4Sensors (Basel, Switzerland) · 2026
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

S JoyceDepartment of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA. Sebastian.Joyce@mcmail.vanderbilt.edu

Funding

MOLECULAR BASIS OF CDLDL AND NATURAL T CELL FUNCTIONR01AI042284 · NIAID · VANDERBILT UNIVERSITY · PI JOYCE, SEBASTIAN · 1998 to 2013
$3.1M
MOLECULAR IMMUNOLOGY OF MINOR HISTOCOMPATIBILITY ANTIGENR01HL054977 · NHLBI · VANDERBILT UNIVERSITY · PI JOYCE, SEBASTIAN · 1995 to 2009
$2.6M
Molecular Basis of CD1d1 and Natural T Cell FunctionR21AI042284 · NIAID · VANDERBILT UNIVERSITY · PI JOYCE, SEBASTIAN · 2002 to 2002
$302k
NHLBI NIH HHS HL 54977NIAID NIH HHS AI 42284
6 · The paper itself

Abstract

Effective immunity to infectious agents requires the initial recognition of antigen by specific receptors, which leads to the activation of immunocytes and the elicitation of an immune response. Because T cell antigen recognition and directed responses are complex processes, they are initiated and quelled in a highly regulated manner. Our laboratory has focused on defining the molecular processes that control T cell antigen presentation and recognition. Research in this area is focused on determining the chemical nature of antigens displayed by Major histocompatibility, complex (MHC)-encoded class I molecules and the nonclassical class I-like protein CD1d. Quantitative aspects of antigen presentation and recognition are also being studied to determine how these factors control the initiation of a T cell response. Our studies provide insights into the biochemical basis of T cell antigen recognition and response as well as the molecular processes underlying the initiation and regulation of immune responses by CD1d-restricted natural T lymphocytes.

Indexed as

Amino Acid SequenceAnimalsAntigen PresentationAntigens, CD1Antigens, CD1dAntiportersCytokinesEndoplasmic ReticulumGolgi ApparatusH-2 AntigensHistocompatibility Antigens Class IHumansImmune SystemImmunoglobulinsKiller Cells, NaturalLigandsAntigens, CD1Antigens, CD1dAntiportersCD1D protein, humanCytokinesH-2 AntigensHistocompatibility Antigens Class IImmunoglobulinsLigandsLipidsMembrane Transport ProteinsReceptors, Antigen, T-Celltapasin

Identifiers

PMID11444386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.