ReviewImmunologic research2001
Regulation of antigen receptor gene assembly in lymphocytes.
Review in Immunologic research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 67 citations in OpenAlex.
- Article
- Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells.The EMBO journal · 2018Article
- Annotation of pseudogenic gene segments by massively parallel sequencing of rearranged lymphocyte receptor loci.Genome medicine · 2015Article
- Evolution of two prototypic T cell lineages.Cellular immunology · 2015Article
- Unique Features of Fish Immune Repertoires: Particularities of Adaptive Immunity Within the Largest Group of Vertebrates.Results and problems in cell differentiation · 2015Review
- Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Estimating the diversity, completeness, and cross-reactivity of the T cell repertoire.Frontiers in immunology · 2013Review
- The actin cytoskeleton coordinates the signal transduction and antigen processing functions of the B cell antigen receptor.Frontiers in biology · 2013Article
- An automated algorithm for extracting functional immunologic V-genes from genomes in jawed vertebrates.Immunogenetics · 2013Article
- Activating interactions of sulfanilamides with T cell receptors.Open journal of immunology · 2013Article
- T cell replicative senescence in human aging.Current pharmaceutical design · 2013Review
- Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- The center of accessibility: Dβ control of V(D)J recombination.Archivum immunologiae et therapiae experimentalis · 2010Review
- The dynamic TCRδ: TCRδ chains in the amphibian Xenopus tropicalis utilize antibody-like V genes.European journal of immunology · 2010Article
- Numerical modelling of the V-J combinations of the T cell receptor TRA/TRD locus.PLoS computational biology · 2010Article
- Promoter activity 5' of Dbeta2 is coordinated by E47, Runx1, and GATA-3.Molecular immunology · 2009Article
- Yeast recombination enhancer is stimulated by transcription activation.Molecular and cellular biology · 2005Article
- Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Immunoglobulin light chain gene rearrangements display hierarchy in absence of selection for functionality in precursor-B-ALL.Leukemia · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Somatic alterations affecting the mammalian genome occur exclusively in B and T cells. Developing lymphocytes employ a series of DNA recombination events (V(D)J recombination) to assemble a diverse repertoire of immunoglobulin (Ig) and T cell receptor (TCR) variable regions from a large array of germline gene segments. V(D)J recombination is required not only for receptor diversification but also for lymphocyte development. At a molecular level, these recombination events are directed by conserved DNA sequences flanking all antigen receptor gene segments that function as recognition signals for a single recombinase activity. Despite these shared features, recombination events are controlled at the levels of stage- and tissue-specificity. Our primary research focus is to dissect the mechanisms that regulate assembly of antigen receptor loci by rendering certain gene segments accessible to a common V(D)J recombinase. This article discusses recent discoveries from the author's laboratory that address this long-standing issue. We have found that transcriptional promoters are critical cis-acting regulatory elements for targeting efficient recombination of chromosomal gene segments. We have also demonstrated that activation of NF-kappaB signaling in precursor B cells is required for global regulation of Ig light chain gene assembly. Together, these findings provide key insights into the genetic mechanisms that regulate antigen receptor diversity and the developmental pathways leading to the acquisition of lymphocyte effector function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.