ArticleJournal of bacteriology2001
Evolution of an autotransporter: domain shuffling and lateral transfer from pathogenic Haemophilus to Neisseria.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Characterization of the Phase-Variable Autotransporter Lav Reveals a Role in Host Cell Adherence and Biofilm Formation in Nontypeable Haemophilus influenzae.Infection and immunity · 2022Article
- Analysis of potential virulence genes and competence to transformation in Haemophilus influenzae biotype aegyptius associated with Brazilian Purpuric Fever.Genetics and molecular biology · 2020Article
- Characterization and Distribution of theFrontiers in cellular and infection microbiology · 2017Article
- Biological Functions of the Secretome ofFrontiers in cellular and infection microbiology · 2017Review
- Expression of the Gene for Autotransporter AutB ofFrontiers in cellular and infection microbiology · 2016Article
- Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence.Cellular and molecular life sciences : CMLS · 2014Review
- Inflammatory response of Haemophilus influenzae biotype aegyptius causing Brazilian Purpuric Fever.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Effects of multi-walled carbon nanotubes (MWCNT) under Neisseria meningitidis transformation process.Journal of nanobiotechnology · 2011Article
- Article
- Serine protease autotransporters of enterobacteriaceae (SPATEs): biogenesis and function.Toxins · 2010Review
- Association of IS1016 with the hia adhesin gene and biotypes V and I in invasive nontypeable Haemophilus influenzae.Infection and immunity · 2008Article
- Subtypes of the plasmid-encoded serine protease EspP in Shiga toxin-producing Escherichia coli: distribution, secretion, and proteolytic activity.Applied and environmental microbiology · 2007Article
- Characterization of igaB, a second immunoglobulin A1 protease gene in nontypeable Haemophilus influenzae.Infection and immunity · 2006Article
- Differential genome contents of nontypeable Haemophilus influenzae strains from adults with chronic obstructive pulmonary disease.Infection and immunity · 2006Article
- Characterization of genetic and phenotypic diversity of invasive nontypeable Haemophilus influenzae.Infection and immunity · 2005Article
- Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20.Journal of bacteriology · 2005Article
- Identification, distribution, and expression of novel genes in 10 clinical isolates of nontypeable Haemophilus influenzae.Infection and immunity · 2005Article
- Codon usage comparison of novel genes in clinical isolates of Haemophilus influenzae.Nucleic acids research · 2005Article
- Type V protein secretion pathway: the autotransporter story.Microbiology and molecular biology reviews : MMBR · 2004Review
- Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The genomes of pathogenic Haemophilus influenzae strains are larger than that of Rd KW20 (Rd), the nonpathogenic laboratory strain whose genome has been sequenced. To identify potential virulence genes, we examined genes possessed by Int1, an invasive nonencapsulated isolate from a meningitis patient, but absent from Rd. Int1 was found to have a novel gene termed lav, predicted to encode a member of the AIDA-I/VirG/PerT family of virulence-associated autotransporters (ATs). Associated with lav are multiple repeats of the tetranucleotide GCAA, implicated in translational phase variation of surface molecules. Laterally acquired by H. influenzae, lav is restricted in distribution to a few pathogenic strains, including H. influenzae biotype aegyptius and Brazilian purpuric fever isolates. The DNA sequence of lav is surprisingly similar to that of a gene previously described for Neisseria meningitidis. Sequence comparisons suggest that lav was transferred relatively recently from Haemophilus to Neisseria, shortly before the divergence of N. meningitidis and Neisseria gonorrhoeae. Segments of lav predicted to encode passenger and beta-domains differ sharply in G+C base content, supporting the idea that AT genes have evolved by fusing domains which originated in different genomes. Homology and base sequence comparisons suggest that a novel biotype aegyptius AT arose by swapping an unrelated sequence for the passenger domain of lav. The unusually mobile lav locus joins a growing list of genes transferred from H. influenzae to Neisseria. Frequent gene exchange suggests a common pool of hypervariable contingency genes and may help to explain the origin of invasiveness in certain respiratory pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.