ArticleJournal of bacteriology2001
Cytotoxic and genotoxic consequences of heat stress are dependent on the presence of oxygen in Saccharomyces cerevisiae.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 65 citations in OpenAlex.
- Comprehensive Analysis of Microbiome, Metabolome, and Transcriptome Revealed the Mechanisms of Intestinal Injury in Rainbow Trout under Heat Stress.International journal of molecular sciences · 2023Article
- MetA is a "thermal fuse" that inhibits growth and protects Escherichia coli at elevated temperatures.Cell reports · 2022Article
- Water is a preservative of microbes.Microbial biotechnology · 2022Article
- Embryonic thermal manipulation impacts the postnatal transcriptome response of heat-challenged Japanese quails.BMC genomics · 2021Article
- Elucidating the Response of Crop Plants towards Individual, Combined and Sequentially Occurring Abiotic Stresses.International journal of molecular sciences · 2021Review
- Toward the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis.Scientific reports · 2021Article
- Improvement of Thermotolerance ofFrontiers in microbiology · 2019Article
- Rational synthetic combination genetic devices boosting high temperature ethanol fermentation.Synthetic and systems biotechnology · 2017Article
- Stress granule-defective mutants deregulate stress responsive transcripts.PLoS genetics · 2014Article
- Revealing the genetic structure of a trait by sequencing a population under selection.Genome research · 2011Article
- Effects of proteinase A on cultivation and viability characteristics of industrial Saccharomyces cerevisiae WZ65.Journal of Zhejiang University. Science. B · 2009Article
- Genetic and physiological alterations occurring in a yeast population continuously propagated at increasing temperatures with cell recycling.World journal of microbiology & biotechnology · 2007Article
- DNA damage induced nucleotide excision repair in Saccharomyces cerevisiae.Molecular and cellular biochemistry · 2006Article
- Identification of genes preferentially expressed in the pathogenic yeast phase of Paracoccidioides brasiliensis, using suppression subtraction hybridization and differential macroarray analysis.Molecular genetics and genomics : MGG · 2004Article
- Oxidative stress and antioxidant response in a thermotolerant yeast.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Lethal heat stress generates oxidative stress in Saccharomyces cerevisiae, and anaerobic cells are several orders of magnitude more resistant than aerobic cells to a 50 degrees C heat shock. Here we characterize the oxidative effects of this heat stress. The thermoprotective effect in anaerobic cells was not due to expression of HSP104 or any other heat shock gene, raising the possibility that the toxicity of lethal heat shock is due mainly to oxidative stress. Aerobic but not anaerobic heat stress caused elevated frequencies of forward mutations and interchromosomal DNA recombination. Oxidative DNA repair glycosylase-deficient strains under aerobic conditions showed a powerful induction of forward mutation frequencies compared to wild-type cells, which was completely abolished under anaerobiosis. We also investigated potential causes for this oxygen-dependent heat shock-induced genetic instability. Levels of sulfhydryl groups, dominated mainly by the high levels of the antioxidant glutathione (reduced form) and levels of vitamin E, decreased after aerobic heat stress but not after anaerobic heat stress. Aerobic heat stress also led to an increase in mitochondrial membrane disruption of several hundredfold, which was 100-fold reduced under anaerobic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.