Evidence map›Paper›PMID 11439326›Full record

ArticleOncogene2001

The HPV E7 oncoprotein inhibits tumor necrosis factor alpha-mediated apoptosis in normal human fibroblasts.

D A Thompson, V Zacny, G S Belinsky, M Classon, D L Jones, R Schlegel, K Münger

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 51 citations in OpenAlex.

  1. Do or Die: HPV E5, E6 and E7 in Cell Death Evasion.Pathogens (Basel, Switzerland) · 2022
    Review
  2. Article
  3. Article
  4. Review
  5. Oncotarget · 2019
    Article
  6. Article
  7. Review
  8. The Interaction Between Human Papillomaviruses and the Stromal Microenvironment.Progress in molecular biology and translational science · 2016
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

D A ThompsonDepartment of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, MA 02115, USA.
V Zacny
G S Belinsky
M Classon
D L Jones
R Schlegel
K Münger
Harvard University · USDana-Farber/Harvard Cancer Center · USMassachusetts General Hospital · USMillennium Engineering and Integration (United States) · US

Funding

MODULATION OF HOST CELL APOPTOTIC RESPONSES BY HPVE7R01CA081135 · NCI · TUFTS UNIVERSITY BOSTON · PI MUNGER, KARL · 2000 to 2014
$4.2M
PROGRAM IN CANCER BIOLOGYT32CA072320 · NCI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI HOWLEY, PETER M · 1997 to 2001
$480k
NCI NIH HHS R01 CA81135NCI NIH HHS T32 CA72320
6 · The paper itself

Abstract

Tumor necrosis factor-alpha (TNF) is a cytokine that induces programmed cell death, apoptosis, in a number of cell types and is employed by cytotoxic T cells to eliminate virus infected cells. Consequently, many viruses have acquired mechanisms to undermine these host cell defense mechanisms and cause resistance to TNF-mediated apoptosis. Here we show that normal human diploid fibroblasts that express the human papillomavirus type 16 E7 oncoprotein have a decreased propensity to undergo apoptosis in response to TNF treatment. The ability of E7 to undermine TNF-mediated apoptosis correlates with cellular transformation. While E7 does not generally subvert signaling by tumor necrosis factor receptor 1, pro-caspase 8 activation is decreased in E7-expressing cells. E7 also provides some protection from apoptosis caused by stimulation of the TNF receptor 1-related cytokine receptor Fas, where induction of apoptosis occurs much slower in this cell type. Hence, E7-expressing normal human fibroblasts exhibit a specific defect that obstructs cytokine-mediated activation of pro-caspase 8 and apoptosis.

Indexed as

Adaptor Proteins, Signal TransducingApoptosisAntigens, CDCarrier ProteinsCaspase 8Caspase 9Caspase InhibitorsCaspasesCell Transformation, NeoplasticEnzyme ActivationEnzyme PrecursorsFas-Associated Death Domain ProteinFibroblastsGene ExpressionHumansI-kappa B KinaseAdaptor Proteins, Signal TransducingAntigens, CDCarrier ProteinsCASP8 protein, humanCASP9 protein, humanCaspase 8Caspase 9Caspase InhibitorsCaspasesCHUK protein, humanEnzyme PrecursorsFADD protein, humanFas-Associated Death Domain ProteinI-kappa B KinaseIKBKB protein, humanIKBKE protein, humanNF-kappa Boncogene protein E7, Human papillomavirus type 16Oncogene Proteins, ViralPapillomavirus E7 ProteinsProteinsProtein Serine-Threonine KinasesReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type ITNF Receptor-Associated Factor 1TNF Receptor-Associated Factor 2Tumor Necrosis Factor-alpha

Identifiers

PMID11439326
OpenAlexW2314592767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.