ArticleProceedings of the National Academy of Sciences of the United States of America2001
C/EBP epsilon mediates myeloid differentiation and is regulated by the CCAAT displacement protein (CDP/cut).
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Genetic susceptibility ofGlobal medical genetics · 2025Article
- Strategies to generate functionally normal neutrophils to reduce infection and infection-related mortality in cancer chemotherapy.Pharmacology & therapeutics · 2019Review
- The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis.Microbiology and molecular biology reviews : MMBR · 2018Review
- Epigenetic regulation of cellular and cytomegalovirus genes during myeloid cell development.Internal medicine review (Washington, D.C. : Online) · 2017Article
- Belinostat, a potent HDACi, exerts antileukaemic effect in human acute promyelocytic leukaemia cells via chromatin remodelling.Journal of cellular and molecular medicine · 2015Article
- HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- C/EBPepsilon directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx.Experimental hematology · 2010Article
- IL-3 and oncogenic Abl regulate the myeloblast transcriptome by altering mRNA stability.PloS one · 2009Article
- PLZF is a regulator of homeostatic and cytokine-induced myeloid development.Genes & development · 2009Article
- Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function.Infection and immunity · 2008Article
- Article
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- Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation.Molecular and cellular biology · 2007Article
- CCAAT displacement protein regulates nuclear factor-kappa beta-mediated chemokine transcription in melanoma cells.Melanoma research · 2007Article
- Differentiation-induced cleavage of Cutl1/CDP generates a novel dominant-negative isoform that regulates mammary gene expression.Molecular and cellular biology · 2006Article
- Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptor.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells.Experimental hematology · 2005Article
- The homeodomain protein CDP regulates mammary-specific gene transcription and tumorigenesis.Molecular and cellular biology · 2004Article
- Gene expression profiling during all-trans retinoic acid-induced cell differentiation of acute promyelocytic leukemia cells.The Journal of molecular diagnostics : JMD · 2003Article
- Transcriptional regulation of myelopoiesis.International journal of hematology · 2002Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Neutrophils from CCAAT enhancer binding protein epsilon (C/EBP epsilon) knockout mice have morphological and biochemical features similar to those observed in patients with an extremely rare congenital disorder called neutrophil-specific secondary granule deficiency (SGD). SGD is characterized by frequent bacterial infections attributed, in part, to the lack of neutrophil secondary granule proteins (SGP). A mutation that results in loss of functional C/EBP epsilon activity has recently been described in an SGD patient, and has been postulated to be the cause of the disease in this patient. We have previously demonstrated that overexpression of CCAAT displacement protein (CDP/cut), a highly conserved transcriptional repressor of developmentally regulated genes, suppresses expression of SGP genes in 32Dcl3 cells. This phenotype resembles that observed in both C/EBP epsilon(-/-) mice and in SGD patients. Based on these observations we investigated potential interactions between C/EBP epsilon and CDP/cut during neutrophil maturation. In this study, we demonstrate that inducible expression of C/EBP epsilon in 32Dcl3/tet cells results in granulocytic differentiation. Furthermore, Northern blot analysis of G-CSF-induced CDP/cut overexpressing 32Dcl3 cells revealed absence of C/EBP epsilon mRNA. We therefore hypothesize that C/EBP epsilon positively regulates SGP gene expression, and that C/EBP epsilon is itself negatively regulated by CDP/cut during neutrophil maturation. We further demonstrate that the C/EBP epsilon promoter is regulated by CDP/cut during myeloid differentiation.
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