ArticleProceedings of the National Academy of Sciences of the United States of America2001
Antagonistic forces generated by myosin II and cytoplasmic dynein regulate microtubule turnover, movement, and organization in interphase cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Dynein-Powered Cell Locomotion Guides Metastasis of Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Regulation of apical constriction via microtubule- and Rab11-dependent apical transport during tissue invagination.Molecular biology of the cell · 2021Article
- Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice.Nature communications · 2021Article
- Profilin 1 delivery tunes cytoskeletal dynamics toward CNS axon regeneration.The Journal of clinical investigation · 2020Article
- Microtubules self-repair in response to mechanical stress.Nature materials · 2015Article
- Photoactivatable green fluorescent protein-tubulin.Methods in cell biology · 2010Review
- Molecular requirements for kinetochore-associated microtubule formation in mammalian cells.Current biology : CB · 2006Article
- Redundant mechanisms for anaphase chromosome movements: crane-fly spermatocyte spindles normally use actin filaments but also can function without them.Protoplasma · 2005Article
- Cytoskeletal coordination during neuronal migration.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- A role for cytoplasmic dynein and LIS1 in directed cell movement.The Journal of cell biology · 2003Article
- Rho-dependent formation of epithelial "leader" cells during wound healing.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Reorganization of the microtubule array in prophase/prometaphase requires cytoplasmic dynein-dependent microtubule transport.The Journal of cell biology · 2002Article
- Dual-wavelength fluorescent speckle microscopy reveals coupling of microtubule and actin movements in migrating cells.The Journal of cell biology · 2002Article
- Centrosome reorientation in wound-edge cells is cell type specific.Molecular biology of the cell · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photoactivation of caged fluorescent tubulin was used mark the microtubule (MT) lattice and monitor MT behavior in interphase cells. A broadening of the photoactivated region occurred as MTs moved bidirectionally. MT movement was not inhibited when MT assembly was suppressed with nocodazole or Taxol; MT movement was suppressed by inhibition of myosin light chain kinase with ML7 or by a peptide inhibitor. Conversely, MT movement was increased after inhibition of cytoplasmic dynein with the antibody 70.1. In addition, the half-time for MT turnover was decreased in cells treated with ML7. These results demonstrate that myosin II and cytoplasmic dynein contribute to a balance of forces that regulates MT organization, movement, and turnover in interphase cells.
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