ArticleProceedings of the National Academy of Sciences of the United States of America2001
The highly recombinogenic bz locus lies in an unusually gene-rich region of the maize genome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 105 citations in OpenAlex.
- Factors determining chromosomal localization of transposable elements in plants.Plant biology (Stuttgart, Germany) · 2025Review
- The plant early recombinosome: a high security complex to break DNA during meiosis.Plant reproduction · 2024Review
- Molecular mechanisms and regulation of recombination frequency and distribution in plants.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Spontaneous mutations in maize pollen are frequent in some lines and arise mainly from retrotranspositions and deletions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Intragenic Meiotic Crossovers Generate Novel Alleles with Transgressive Expression Levels.Molecular biology and evolution · 2018Article
- ZmSTK1 and ZmSTK2, encoding receptor-like cytoplasmic kinase, are involved in maize pollen development with additive effect.Plant biotechnology journal · 2018Article
- Competitive Ability of Maize Pollen Grains Requires Paralogous Serine Threonine Protein Kinases STK1 and STK2.Genetics · 2017Article
- High-Resolution Mapping of Crossover Events in the Hexaploid Wheat Genome Suggests a Universal Recombination Mechanism.Genetics · 2017Article
- Complexity of genetic mechanisms conferring nonuniformity of recombination in maize.Scientific reports · 2017Article
- DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination in Arabidopsis.Genes & development · 2015Article
- Article
- Phylogenetic analysis of STK gene family and Usp domain in maize.Molecular biology reports · 2014Article
- Polarized gene conversion at the bz locus of maize.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Adaptive expansion of the maize maternally expressed gene (Meg) family involves changes in expression patterns and protein secondary structures of its members.BMC plant biology · 2014Article
- Article
- The spectrum and frequency of self-inflicted and host gene mutations produced by the transposon Ac in maize.The Plant cell · 2012Article
- Fine-scale population recombination rates, hotspots, and correlates of recombination in the Medicago truncatula genome.Genome biology and evolution · 2012Article
- Characterization of transposable elements in the ectomycorrhizal fungus Laccaria bicolor.PloS one · 2012Article
- Molecular characterization of a genomic interval with highly uneven recombination distribution on maize chromosome 10 L.Genetica · 2011Article
- Genome size and transposable element content as determined by high-throughput sequencing in maize and Zea luxurians.Genome biology and evolution · 2011Article
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6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bronze (bz) locus exhibits the highest rate of recombination of any gene in higher plants. To investigate the possible basis of this high rate of recombination, we have analyzed the physical organization of the region around the bz locus. Two adjacent bacterial artificial chromosome clones, comprising a 240-kb contig centered around the Bz-McC allele, were isolated, and 60 kb of contiguous DNA spanning the two bacterial artificial chromosome clones was sequenced. We find that the bz locus lies in an unusually gene-rich region of the maize genome. Ten genes, at least eight of which are shown to be transcribed, are contained in a 32-kb stretch of DNA that is uninterrupted by retrotransposons. We have isolated nearly full length cDNAs corresponding to the five proximal genes in the cluster. The average intertranscript distance between them is just 1 kb, revealing a surprisingly compact packaging of adjacent genes in this part of the genome. At least 11 small insertions, including several previously described miniature inverted repeat transposable elements, were detected in the introns and 3' untranslated regions of genes and between genes. The gene-rich region is flanked at the proximal and distal ends by retrotransposon blocks. Thus, the maize genome appears to have scattered regions of high gene density similar to those found in other plants. The unusually high rate of intragenic recombination seen in bz may be related to the very high gene density of the region.
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