ArticleProceedings of the National Academy of Sciences of the United States of America2001
The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 81 citations in OpenAlex.
- Infant acute lymphoblastic leukemia - combined cytogenetic, immunophenotypical and molecular analysis of 77 cases.Leukemia · 2002Trial
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- Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA.Briefings in bioinformatics · 2022Article
- Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD.BMC immunology · 2022Article
- Microarrays-Enabled Hypothesis Generation: The Suspect Role of FNBP-1 in Neuropsychiatric Pathogenesis Associated with HIV and/or HCV Infection.Journal of AIDS & clinical research · 2016Article
- F-BAR family proteins, emerging regulators for cell membrane dynamic changes-from structure to human diseases.Journal of hematology & oncology · 2015Review
- Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.Physiological reviews · 2012Review
- A presynaptic endosomal trafficking pathway controls synaptic growth signaling.The Journal of cell biology · 2011Article
- Attachment of rod-like (BAR) proteins and membrane shape.Mini reviews in medicinal chemistry · 2011Review
- Transducer of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasiveness.The Journal of biological chemistry · 2011Article
- PhenoFam-gene set enrichment analysis through protein structural information.BMC bioinformatics · 2010Article
- The F-BAR protein family Actin' on the membrane.Communicative & integrative biology · 2010Article
- The molecular biology of mixed lineage leukemia.Haematologica · 2009Review
- Estrogen regulates vesicle trafficking gene expression in EFF-3, EFM-19 and MCF-7 breast cancer cells.International journal of clinical and experimental pathology · 2009Article
- Article
- ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility and axon outgrowth.Molecular and cellular neurosciences · 2007Article
- SEPT2 is a new fusion partner of MLL in acute myeloid leukemia with t(2;11)(q37;q23).Oncogene · 2006Article
- Molecular pathogenesis of MLL-associated leukemias.International journal of hematology · 2005Review
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have cloned a fusion partner of the MLL gene at 11q23 and identified it as the gene encoding the human formin-binding protein 17, FBP17. It maps to chromosome 9q34 centromeric to ABL. The gene fusion results from a complex chromosome rearrangement that was resolved by fluorescence in situ hybridization with various probes on chromosomes 9 and 11 as an ins(11;9)(q23;q34)inv(11)(q13q23). The rearrangement resulted in a 5'-MLL/FBP17-3' fusion mRNA. We retrovirally transduced murine-myeloid progenitor cells with MLL/FBP17 to test its transforming ability. In contrast to MLL/ENL, MLL/ELL and other MLL-fusion genes, MLL/FBP17 did not give a positive readout in a serial replating assay. Therefore, we assume that additional cooperating genetic abnormalities might be needed to establish a full malignant phenotype. FBP17 consists of a C-terminal Src homology 3 domain and an N-terminal region that is homologous to the cell division cycle protein, cdc15, a regulator of the actin cytoskeleton in Schizosaccharomyces pombe. Both domains are separated by a consensus Rho-binding motif that has been identified in different Rho-interaction partners such as Rhotekin and Rhophilin. We evaluated whether FBP17 and members of the Rho family interact in vivo with a yeast two-hybrid assay. None of the various Rho proteins tested, however, interacted with FBP17. We screened a human kidney library and identified a sorting nexin, SNX2, as a protein interaction partner of FBP17. These data provide a link between the epidermal growth factor receptor pathway and an MLL fusion protein.
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