ArticleMolecular and cellular biology2001
Investigation of elements sufficient to imprint the mouse Air promoter.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Sequence determinants, function, and evolution of CpG islands.Biochemical Society transactions · 2021Review
- Linking RNA biology to lncRNAs.Genome research · 2015Review
- Tissue-specific regulation of Igf2r/Airn imprinting during gastrulation.Epigenetics & chromatin · 2015Article
- The long non-coding RNA Fendrr links epigenetic control mechanisms to gene regulatory networks in mammalian embryogenesis.RNA biology · 2013Article
- Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation.Epigenetics & chromatin · 2013Article
- Transgenic epigenetics: using transgenic organisms to examine epigenetic phenomena.Genetics research international · 2012Article
- Regulatory RNAs in brain function and disorders.Brain research · 2010Review
- Transcription is required for establishment of germline methylation marks at imprinted genes.Genes & development · 2009Article
- Article
- Specific differentially methylated domain sequences direct the maintenance of methylation at imprinted genes.Molecular and cellular biology · 2006Article
- The imprinted Air ncRNA is an atypical RNAPII transcript that evades splicing and escapes nuclear export.The EMBO journal · 2006Article
- The silence RNA keeps: cis mechanisms of RNA mediated epigenetic silencing in mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements.Genome research · 2005Article
- Analysis of imprinted murine Peg3 locus in transgenic mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- The Air noncoding RNA: an imprinted cis-silencing transcript.Cold Spring Harbor symposia on quantitative biology · 2004Review
- Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus.Molecular and cellular biology · 2003Article
- Shared role for differentially methylated domains of imprinted genes.Molecular and cellular biology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imprinted maternal-allele-specific expression of the mouse insulin-like growth-factor type 2 receptor (Igf2r) gene depends on a 3.7-kb element named region 2, located in the second intron of the gene. Region 2 carries a maternal-allele-specific methylation imprint and contains an imprinted CpG island promoter (Air) that expresses a noncoding antisense RNA from the paternal inherited allele only. Here, we use transgenes to test the minimal requirements for imprinting of Air and to test if the action of region 2 is restricted to Igf2r. Transgenes up to 9 kb with Air as a single promoter are expressed but not imprinted. When coupled to the Igf2r CpG island promoter on a 44-kb transgene, Air was imprinted in one of three lines. However, Air on a 4.6-kb fragment is also imprinted in 2 of 14 lines when inserted in an intron of an adenine phosphoribosyltransferase (Aprt) transgene, and in one line, the imprinted methylation and expression of Air have been transferred onto the Aprt CpG island promoter. These data suggest that a dual CpG island promoter setting may facilitate Air imprinting as a short transgene and also show that Air can transfer imprinting onto other genes. However, for reliable Air imprinting, elements are necessary that are located outside a 44-kb region spanning the Air-Igf2r promoters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.