ArticleMolecular and cellular biology2001
Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 94 citations in OpenAlex.
- Upstream open reading frames: new players in the landscape of cancer gene regulation.NAR cancer · 2024Review
- The molecular architecture of cell cycle arrest.Molecular systems biology · 2022Article
- Critical Role for Cap-Independent c-MYC Translation in Progression of Multiple Myeloma.Molecular cancer therapeutics · 2022Article
- Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita.Nature genetics · 2019Article
- Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27Kip1.Nucleic acids research · 2018Article
- Cell cycle RNA regulons coordinating early lymphocyte development.Wiley interdisciplinary reviews. RNA · 2017Review
- PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1.Nucleic acids research · 2017Article
- Cap-Independent Translational Control of Carcinogenesis.Frontiers in oncology · 2016Review
- Translate to divide: сontrol of the cell cycle by protein synthesis.Microbial cell (Graz, Austria) · 2015Review
- A novel mutation in the upstream open reading frame of the CDKN1B gene causes a MEN4 phenotype.PLoS genetics · 2013Article
- Mammalian target of rapamycin inhibitors induce tumor cell apoptosis in vivo primarily by inhibiting VEGF expression and angiogenesis.Journal of oncology · 2013Article
- Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis.Cell reports · 2012Article
- High levels of Hdmx promote cell growth in a subset of uveal melanomas.American journal of cancer research · 2012Article
- Far upstream element binding protein 1 activates translation of p27Kip1 mRNA through its internal ribosomal entry site.The international journal of biochemistry & cell biology · 2011Article
- Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucine.Cancer cell international · 2011Article
- Oncogenic AKTivation of translation as a therapeutic target.British journal of cancer · 2011Review
- Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis.Cancer research · 2010Article
- Article
- Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids.Cancer cell international · 2010Article
- miR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cells.Molecular and cellular biology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
p27 is a key regulator of cell proliferation through inhibition of G(1) cyclin-dependent kinase (CDK) activity. Translation of the p27 mRNA is an important control mechanism for determining cellular levels of the inhibitor. Nearly all eukaryotic mRNAs are translated through a mechanism involving recognition of the 5' cap by eukaryotic initiation factor 4E (eIF4E). In quiescent cells eIF4E activity is repressed, leading to a global decline in translation rates. In contrast, p27 translation is highest during quiescence, suggesting that it escapes the general repression of translational initiation. We show that the 5' untranslated region (5'-UTR) of the p27 mRNA mediates cap-independent translation. This activity is unaffected by conditions in which eIF4E is inhibited. In D6P2T cells, elevated cyclic AMP levels cause a rapid withdrawal from the cell cycle that is correlated with a striking increase in p27. Under these same conditions, cap-independent translation from the p27 5'-UTR is enhanced. These results indicate that regulation of internal initiation of translation is an important determinant of p27 protein levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.