ArticleMolecular and cellular biology2001
Cdc5 interacts with the Wee1 kinase in budding yeast.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Cdc5-mediated Ulp2 phosphorylation controls the timing of polySUMOylation during the cell cycle.The Journal of cell biology · 2026Article
- Polo-like kinase Cdc5 orchestrates Cdk1 regulation via Swe1 and Mih1 during meiotic prophase I exit.Communications biology · 2026Article
- Moonlighting at the Poles: Non-Canonical Functions of Centrosomes.Frontiers in cell and developmental biology · 2022Review
- Divide Precisely and Proliferate Safely: Lessons From Budding Yeast.Frontiers in genetics · 2018Article
- Fundamental cell cycle kinases collaborate to ensure timely destruction of the synaptonemal complex during meiosis.The EMBO journal · 2017Article
- Budding yeast Wee1 distinguishes spindle pole bodies to guide their pattern of age-dependent segregation.Nature cell biology · 2017Article
- PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase.Scientific reports · 2015Article
- The budding yeast Polo-like kinase Cdc5 is released from the nucleus during anaphase for timely mitotic exit.Cell cycle (Georgetown, Tex.) · 2014Article
- The role of autophagy in genome stability through suppression of abnormal mitosis under starvation.PLoS genetics · 2013Article
- Impaired manganese metabolism causes mitotic misregulation.The Journal of biological chemistry · 2012Article
- Acm1 contributes to nuclear positioning by inhibiting Cdh1-substrate interactions.Cell cycle (Georgetown, Tex.) · 2012Article
- The budding yeast polo-like kinase Cdc5 regulates the Ndt80 branch of the meiotic recombination checkpoint pathway.Molecular biology of the cell · 2011Article
- CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation.PLoS biology · 2010Article
- Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway.PLoS genetics · 2010Article
- Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle.Nature cell biology · 2008Article
- Cdc25 and Wee1: analogous opposites?Cell division · 2007Article
- Article
- Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Review
- Regulation of cell cycle checkpoints by polo-like kinases.Oncogene · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of a multicellular organism requires that mitosis and morphogenesis be coordinated. These processes must also be synchronized during the growth of unicellular organisms. In the yeast Saccharomyces cerevisiae, mitosis is dependent on the prior growth of a daughter cell in the form of a bud. Overexpression of wild-type Polo-like kinase Cdc5 or a catalytically inactive form resulted in the formation of multinucleate cells in budding yeast. Immunofluorescence analysis of these multinulceate cells showed that mitosis and bud formation were no longer linked. Others have shown that Swe1 is required for coupling mitosis to bud formation during a perturbed cell cycle. When the normal pathway of bud formation is perturbed, Swe1 functions to delay mitosis through negative regulation of Clb/Cdk. In cells lacking Swe1, multinucleate cells are formed in response to delays in bud formation. Affinity purification, two-hybrid analysis, and mutant characterization results suggested that Cdc5 and Swe1 interact. From these results, we conclude that multinucleate formation in response to Cdc5 overexpression is linked to titration of Swe1 function. These results also suggest that Cdc5 may be a negative regulator of Swe1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.